{"created":"2023-07-27T06:55:37.017728+00:00","id":51692,"links":{},"metadata":{"_buckets":{"deposit":"18167370-83f5-4876-855c-b02b18364748"},"_deposit":{"created_by":18,"id":"51692","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51692"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051692","sets":["2812:2813:4014"]},"author_link":["74055","93"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"26p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生活習慣病の増加と共に増加するNASHの成因は不明であり、有効な治療法は存在しない。申請者らは、ハイスループットで多検体のリン酸化解析を網羅的に解析する新技術プロテインアレイを確立し、マウスNASH肝発がんモデル及びNAFLD/NASH症例のリン酸化プロファイルを明らかにした。NASH病態の進行と関連する特に変動の大きな13遺伝子の中には、液性因子レセプターが含まれ、創薬の候補になり得ると考えられた。また、NASH肝癌の新たな治療標的分子としてV-ATPaseファミリー遺伝子を同定した。","subitem_description_type":"Abstract"},{"subitem_description":"NASH is closely associated with the increase in lifestyle-related diseases and effective therapy to NASH is now under development. We developed high throughput phosphoproteome analysis system and examined liver tissues of mouse NSAH model and the patients of NASH. We identified 13 genes associated with NASH progressions and one of them was receptor of soluble factor. We also newly identified the hyper phospholylation of V-ATPase family genes in NASH-HCC. These genes could be new targets to prevent the progression of NASH and the therapy to treat NASH related HCC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18H02793, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「NAFLD/NASH肝組織リン酸化活性プロファイリングと新規治療標的分子の同定」研究成果報告書　課題番号18H02793\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02793/18H02793seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057995","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00272980"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00272980","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02793/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02793/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02793/18H02793seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02793/18H02793seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-18"}],"displaytype":"detail","filename":"ME-PR-HONDA-M-kaken 2021-26p.pdf","filesize":[{"value":"438.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HONDA-M-kaken 2021-26p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51692/files/ME-PR-HONDA-M-kaken 2021-26p.pdf"},"version_id":"b98039c3-7a0a-4f5c-b54b-754f9fe87802"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"NAFLD/NASH肝組織リン酸化活性プロファイリングと新規治療標的分子の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NAFLD/NASH肝組織リン酸化活性プロファイリングと新規治療標的分子の同定"},{"subitem_title":"Phosphoproteome analysis of the liver tissues with NAFLD/NASH and identification of therapeutic targets.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-18"},"publish_date":"2022-02-18","publish_status":"0","recid":"51692","relation_version_is_last":true,"title":["NAFLD/NASH肝組織リン酸化活性プロファイリングと新規治療標的分子の同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:50:06.958826+00:00"}