{"created":"2023-07-27T06:55:37.247565+00:00","id":51697,"links":{},"metadata":{"_buckets":{"deposit":"969806f6-da6a-4f1c-a14f-d270193193a0"},"_deposit":{"created_by":18,"id":"51697","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51697"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051697","sets":["2812:2813:4014"]},"author_link":["75509","233"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"12p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、多発性硬化症及びその動物モデルEAEの病態形成に小胞体ストレスが関与することが示唆されている。我々は、小胞体ストレス応答因子ATF6bの発現および機能について、EAEモデルを用いて検討した。野生型マウスにEAEを誘導すると、ATF6bの発現は脊髄の神経細胞およびオリゴデンドロサイトで増加した。次に野生型及びATF6bKOマウスで同様の実験を行うと、後者において運動麻痺、脱髄の悪化が認められた。以上より、ATF6bはEAE病態下の神経またはオリゴデンドロサイトを保護している可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"It has been reported that endoplasmic reticulum (ER) stress is involved in the pathology of multiple sclerosis and its experimental animal model, EAE. We, therefore, studied the expression and the possible role of ATF6b, an ER stress-related gene, in a mouse EAE model. When EAE was introduced to WT mice, ATF6b was upregulated in both neurons and oligodendrocytes in the spinal cord. Furthermore, when similar experiments were performed with AFT6b KO mice, the paralysis and demyelination was severer than those in WT mice. These results suggest that ATF6b protects neurons and oligodendrocytes in the pathology of EAE.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K06500, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「多発性硬化症モデルマウスにおける小胞体ストレス応答因子ATF6betaの重要性」研究成果報告書　課題番号18K06500\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K06500/18K06500seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058000","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60303947"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60303947","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06500/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06500/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K06500/18K06500seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K06500/18K06500seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-18"}],"displaytype":"detail","filename":"ME-PR-HORI-O-kaken 2021-12p.pdf","filesize":[{"value":"666.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HORI-O-kaken 2021-12p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51697/files/ME-PR-HORI-O-kaken 2021-12p.pdf"},"version_id":"4257f166-a1e3-45e0-b64f-1827f00b5ebd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"多発性硬化症モデルマウスにおける小胞体ストレス応答因子ATF6betaの重要性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"多発性硬化症モデルマウスにおける小胞体ストレス応答因子ATF6betaの重要性"},{"subitem_title":"Role of the ER stress-related molecule ATF6b in a mouse model of multiple sclerosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-18"},"publish_date":"2022-02-18","publish_status":"0","recid":"51697","relation_version_is_last":true,"title":["多発性硬化症モデルマウスにおける小胞体ストレス応答因子ATF6betaの重要性"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:50:04.756281+00:00"}