{"created":"2023-07-27T06:55:38.295852+00:00","id":51726,"links":{},"metadata":{"_buckets":{"deposit":"ea66919d-3926-4911-9962-ff37046a68da"},"_deposit":{"created_by":18,"id":"51726","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51726"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051726","sets":["2812:2813:3929"]},"author_link":["22167","2081"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"シスプラチンは骨浸潤した腫瘍に対しての制御が悪く、腎機能障害が問題である。こうした背景からシスプラチンにリン酸基をつけ電荷型にした薬剤が開発された（3Pt)。頭頸部癌細胞株を用いて、3Ptとシスプラチンの抗腫瘍,腎機能障害について検討した。頭頸部癌移植モデルマウスを用いた検討では、両者の薬剤は抗腫瘍効果については同等であった。また3ptが腎機能障害が軽減していた。さらに舌癌細胞株を下顎骨に移植したモデルマウスにおいて3Pt投与群がコントロール群やシスプラチン群に比べて、下顎骨の骨破壊の抑制効果が高かった。3Ptは骨浸潤のあるような腫瘍において高い抗腫瘍効果と腎機能障害の軽減が図れる。","subitem_description_type":"Abstract"},{"subitem_description":"Cisplatin (CDDP) is an important drug for chemotherapy in patients with head and neck squamous cell carcinoma. To increase its antitumor effect on bone invasion and reduce toxicity problems, anionic Pt complex (3Pt) has been developed. The present study aimed to characterize the basis of the cytotoxicity of the novel platinum complex 3Pt in comparison with that of CDDP . Both 3Pt and CDDP showed equivalent antitumor effects in vivo. Mice injected with CDDP developed renal cell apoptosis; however, those injected with 3Pt were almost free of renal cell injury. In addition to similar in vivo antitumor effects, 3Pt decreased the volume of bone resorption compared to that with CDDP in a bone invasion model using OSC-19. In conclusion, considering the potential advantages in terms of noticeable antitumor activity on bone invasion and reduced nephrotoxicity, 3Pt represents a significant improvement in the development of bone-targeting platinum drug.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K11227, 研究期間(年度):2016-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ミセル化パクリタキセルによる頭頸部癌次世代治療戦略と薬剤耐性克服への応用」研究成果報告書　課題番号16K11227\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K11227/16K11227seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院耳鼻咽喉科・頭頸部外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058029","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30547154"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30547154","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11227/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11227/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K11227/16K11227seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K11227/16K11227seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"HO-PR-ENDO-K-kaken 2020-4p.pdf","filesize":[{"value":"358.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-ENDO-K-kaken 2020-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51726/files/HO-PR-ENDO-K-kaken 2020-4p.pdf"},"version_id":"a3a8df26-6715-46b2-84d3-1b23d52c37b3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ミセル化パクリタキセルによる頭頸部癌次世代治療戦略と薬剤耐性克服への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミセル化パクリタキセルによる頭頸部癌次世代治療戦略と薬剤耐性克服への応用"},{"subitem_title":"Bone invasion-targeted chemotherapy with a novel anionic platinum complex (3Pt) for oral squamous cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-30"},"publish_date":"2021-04-30","publish_status":"0","recid":"51726","relation_version_is_last":true,"title":["ミセル化パクリタキセルによる頭頸部癌次世代治療戦略と薬剤耐性克服への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:06:52.684824+00:00"}