{"created":"2023-07-27T06:55:38.749574+00:00","id":51740,"links":{},"metadata":{"_buckets":{"deposit":"c49fb85f-c2ca-4a4c-9a8f-3ef3031c55ae"},"_deposit":{"created_by":18,"id":"51740","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51740"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051740","sets":["2812:2813:4085"]},"author_link":["78891","78892"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"17p.","bibliographicVolumeNumber":"2018-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Goto, Kyoko"}],"nameIdentifiers":[{"nameIdentifier":"78892","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50180245","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50180245"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Over 50 novel natural products were isolated from phytochemically untouched rainforest plants, elucidated their chemical structure, and evaluated for antiproliferative activity against tumor cell lines. The synthetic routs of bioactive natural products were developed, and various derivatives were synthesized. The structure-activity relationships and their mechanisms of action of bioactive derivatives were also investigated.","subitem_description_type":"Abstract"},{"subitem_description":"植物化学的な精査が行われていない熱帯雨林産植物8種より、ユニークな化学構造を含む50種以上の新規天然物を単離精製し、それらの化学構造を決定した。さらに、有望な抗腫瘍活性が認められた天然物5種については、全合成ルートの開発、誘導体合成による構造活性相関研究、作用機序の解明の一連の研究を行い、それぞれについて創薬シードとしての可能性を提示した。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18H02583, 研究期間(年度):2018-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「希少熱帯資源から新規創薬リードへの展開」課題番号18H02583\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18H02583/18H02583seika/ ）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058043","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50180245"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50180245","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02583/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02583/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18H02583/18H02583seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18H02583/18H02583seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"後藤, 享子"}],"nameIdentifiers":[{"nameIdentifier":"78891","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50180245","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50180245"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-06"}],"displaytype":"detail","filename":"PH-PR-GOTO-K-kaken 2022-17p.pdf","filesize":[{"value":"291.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-GOTO-K-kaken 2022-17p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51740/files/PH-PR-GOTO-K-kaken 2022-17p.pdf"},"version_id":"2049d366-34b5-465f-a409-cf3eb83cea6b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"希少熱帯資源から新規創薬リードへの展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"希少熱帯資源から新規創薬リードへの展開"},{"subitem_title":"Development of novel drug leads based on rare tropical resources","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-06"},"publish_date":"2023-02-06","publish_status":"0","recid":"51740","relation_version_is_last":true,"title":["希少熱帯資源から新規創薬リードへの展開"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:15:50.576308+00:00"}