{"created":"2023-07-27T06:55:38.929973+00:00","id":51747,"links":{},"metadata":{"_buckets":{"deposit":"1b6e1591-8f37-46f0-9e13-ef5f952fb579"},"_deposit":{"created_by":18,"id":"51747","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51747"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051747","sets":["2812:2813:3929"]},"author_link":["76678","76677"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸がん治療のKey drugであるオキサリプラチン（L-OHP）を末梢静脈から投与した際に生じる血管痛の発現機序および有効な予防対策の確立に取り組んだ。その結果、L-OHPによる血管痛は、プロカイン、ルテニウムレッド（TRP非選択的阻害薬）、HC030031（TRPA1選択的阻害薬）、PBN（抗酸化剤）で抑制された。この結果から、L-OHPによる血管痛には、TRPA1および活性酸素が関与していることが明らかとなった。TRPA1の活性化を抑制できる抗酸化剤は、有効性の高い血管痛の予防対策となる可能性があると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of this study is to elucidate the mechanism of vascular pain caused by oxaliplatin (L-OHP), a key drug for treatment of colorectal cancer, and to establish effective preventive methods in clinical practice. L-OHP-induced vascular pain was suppressed by procaine, ruthenium red (TRP non-selective inhibitor), HC030031 (TRPA1 selective inhibitor), and PBN (antioxidant). The TRPA1 suppressive therapy could be considered as highly effective preventive methods against L-OHP-induced vascular pain.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K08397, 研究期間(年度):2016-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「がん薬物療法における血管痛発現機序の解明および新規予防法の開発」研究成果報告書　課題番号16K08397\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08397/16K08397seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058050","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00467101"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00467101","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08397/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08397/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08397/16K08397seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08397/16K08397seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"PH-SUGA-Y-kaken 2020-5p.pdf","filesize":[{"value":"302.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-SUGA-Y-kaken 2020-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51747/files/PH-SUGA-Y-kaken 2020-5p.pdf"},"version_id":"9910855c-7857-41ae-a4da-7ea7c4b84184"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん薬物療法における血管痛発現機序の解明および新規予防法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん薬物療法における血管痛発現機序の解明および新規予防法の開発"},{"subitem_title":"Development of new preventive strategy and elucidation of mechanism for cancer chemotherapy-induced vascular pain","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-30"},"publish_date":"2021-04-30","publish_status":"0","recid":"51747","relation_version_is_last":true,"title":["がん薬物療法における血管痛発現機序の解明および新規予防法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:07:01.507388+00:00"}