{"created":"2023-07-27T06:55:39.527549+00:00","id":51775,"links":{},"metadata":{"_buckets":{"deposit":"c3737ba1-93bb-41cb-b120-25fa4dae04ce"},"_deposit":{"created_by":18,"id":"51775","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51775"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051775","sets":["2812:2813:4085"]},"author_link":["227","71948"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"10p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this project, we have studied the role of inflammatory and fibrotic microenvironment in the liver metastasis of intestinal tumor cells. For this purpose, we have established mouse intestinal tumor-derived organoids carrying major driver mutations of colon cancer, and generated liver metastasis models by transplantation of these organoids to the spleen. We found that fibrotic microenvironment was generated surrounding the disseminated tumor cells by activation of hepatic stellate cells, which support survival and proliferation of the disseminated tumor cells, leading to development of metastatic foci. Moreover, we found that host TGF-β signaling is required for generation of fibrotic niche and development of metastatic foci in the liver. Moreover, host innate immune response and inflammatory pathway also contributed to the metastatic foci formation. These results expand our knowledge about the role of microenvironment in colon cancer metastasis.","subitem_description_type":"Abstract"},{"subitem_description":"炎症反応や線維性微小環境の形成は、発がんに重要な役割を果たすことが示されているが、転移などの悪性化過程における役割は未だ不明な点が多い。本研究では、マウス腸管腫瘍由来オルガノイドの移植モデルを用いて、大腸がん肝転移機構の解析を行なった。その結果、転移性がん細胞が肝臓に到達すると、肝星細胞の活性化により線維性微小環境が形成され、がん細胞の生存と増殖を促進することが明らかとなった。さらに、宿主側のTGF-βシグナルや自然免疫、炎症反応が、線維性微小環境形成と肝転移巣形成に重要な役割を果たすことが、個体レベルの解析により明らかとなった。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19H03498, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「炎症性・線維性微小環境による大腸がん転移促進機構の解明」課題番号19H03498\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19H03498/19H03498seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058078","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80362515"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80362515","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03498/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03498/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19H03498/19H03498seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19H03498/19H03498seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-06"}],"displaytype":"detail","filename":"CA-PR-OSHIMA-H-kaken 2022-10p.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-OSHIMA-H-kaken 2022-10p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51775/files/CA-PR-OSHIMA-H-kaken 2022-10p.pdf"},"version_id":"751f32e5-946f-4b96-bc59-354995e98824"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症性・線維性微小環境による大腸がん転移促進機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症性・線維性微小環境による大腸がん転移促進機構の解明"},{"subitem_title":"Inflammatory and fibrotic microenvironment in promotion of liver metastasis of colon cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-06"},"publish_date":"2023-02-06","publish_status":"0","recid":"51775","relation_version_is_last":true,"title":["炎症性・線維性微小環境による大腸がん転移促進機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:37:30.591722+00:00"}