{"created":"2023-07-27T06:55:39.618052+00:00","id":51778,"links":{},"metadata":{"_buckets":{"deposit":"256a6556-95ae-42e0-b970-ec992241ad20"},"_deposit":{"created_by":18,"id":"51778","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51778"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051778","sets":["2812:2813:4085"]},"author_link":["2843","85743"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the tumor promoting role of GSK3β by focusing on nutrient acquisition mechanism in cancer cells, and clarified the effect of GSK3β on lactate production and induction of autophagy in colon cancer. Analysis of the efficacy of combined treatment with GSK3β inhibitor and autophagy inhibitor for cell growth and of its mechanism suggest that nutrient acquisition mechanism may be as a promising therapeutic target for cancer treatment.","subitem_description_type":"Abstract"},{"subitem_description":"大腸がん細胞におけるGSK3βのがん促進作用をがん細胞の栄養獲得機構に焦点を当てて解析し、乳酸産生・分泌とオートファジー誘導に対するGSK3βの作用を見出した。また、GSK3β阻害剤とオートファジー阻害剤併用による細胞増殖に対する効果とその分子機構の解析から、両阻害剤の併用により、がん細胞の栄養獲得機構を標的とした効率的ながん治療法の開発につながることが示唆された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K07710, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「GSK3βによるがん促進的糖代謝特性の解明と制御への応用」課題番号19K07710\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07710/19K07710seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058081","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80635540"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80635540","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07710/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07710/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07710/19K07710seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07710/19K07710seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-06"}],"displaytype":"detail","filename":"CA-PR-DOMOTO-T-kaken 2022-8p.pdf","filesize":[{"value":"295.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-DOMOTO-T-kaken 2022-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51778/files/CA-PR-DOMOTO-T-kaken 2022-8p.pdf"},"version_id":"b57551f1-6cd7-4060-adc4-7929177ac81c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"GSK3βによるがん促進的糖代謝特性の解明と制御への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GSK3βによるがん促進的糖代謝特性の解明と制御への応用"},{"subitem_title":"Exploring the characteristics of tumor-promoting glycometabolism enhanced by GSK3beta toward application to cancer therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-06"},"publish_date":"2023-02-06","publish_status":"0","recid":"51778","relation_version_is_last":true,"title":["GSK3βによるがん促進的糖代謝特性の解明と制御への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:37:29.736592+00:00"}