{"created":"2023-07-27T06:55:39.662479+00:00","id":51779,"links":{},"metadata":{"_buckets":{"deposit":"9b868f8b-9d0b-465a-9062-9a7505460eb5"},"_deposit":{"created_by":18,"id":"51779","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51779"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051779","sets":["2812:2813:4085"]},"author_link":["85745","1910"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishimura, Akihiko"}],"nameIdentifiers":[{"nameIdentifier":"85745","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80375261","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80375261"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epigenetic mutations in tumors alter the genomic environment, leading to the activation of oncogenes or inactivation of tumor suppressor genes. The alteration is involved in the acquisition of various cancer malignant phenotypes such as invasion, metastasis, stemness and drug resistance.\nIn order to identify essential epigenetic regulators relating to breast cancer malignancy, we performed CRISPR/Cas9 screening using a lentiviral sgRNA library composed of 120 kinds of epigenetic regulators. As a result, we identified KDM3B, one of the histone demethylases, as a breast cancer malignant factor. Cell biological studies and clinical data strongly suggest that KDM3B is a novel tumor suppressor in malignant breast cancer.","subitem_description_type":"Abstract"},{"subitem_description":"腫瘍内のエピジェネティック変異は、遺伝子の取り巻くゲノム環境を変化させ、がん遺伝子の活性化やがん抑制遺伝子の不活性化を引き起こす。その結果、浸潤・転移、がん幹細胞性、薬剤耐性といった様々ながん悪性形質の獲得に関与すると考えられている。\n本研究では、120種類のエピジェネティック制御に関係する遺伝子から構成されたsgRNAライブラリーを作製し、がん悪性化に関わる標的遺伝子のスクリーニングを試みた。その結果、ヒストン脱メチル化酵素KDM3Bを含む複数の遺伝子を新規の乳がん悪性化因子として同定した。今後、乳がん悪性化における作用機構を分子レベルで明らかにする。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K07686, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「がん悪性形質獲得に関係するエピジェネティック制御因子の探索」課題番号19K07686\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07686/19K07686seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058082","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80375261"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80375261","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07686/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07686/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07686/19K07686seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07686/19K07686seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石村, 昭彦"}],"nameIdentifiers":[{"nameIdentifier":"1910","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80375261","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80375261"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-06"}],"displaytype":"detail","filename":"CA-PR-ISHIMURA-A-kaken 2022-5p.pdf","filesize":[{"value":"429.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-ISHIMURA-A-kaken 2022-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51779/files/CA-PR-ISHIMURA-A-kaken 2022-5p.pdf"},"version_id":"1ddc1be5-9f1e-410b-b3d1-3911fe562fcf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん悪性形質獲得に関係するエピジェネティック制御因子の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん悪性形質獲得に関係するエピジェネティック制御因子の探索"},{"subitem_title":"CRISPR/Cas9 screening of epigenetic factors relating to cancer malignancy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-06"},"publish_date":"2023-02-06","publish_status":"0","recid":"51779","relation_version_is_last":true,"title":["がん悪性形質獲得に関係するエピジェネティック制御因子の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:18:22.106698+00:00"}