{"created":"2023-07-27T06:55:39.752551+00:00","id":51782,"links":{},"metadata":{"_buckets":{"deposit":"5397f3c9-458b-4f83-98ed-008f307b9e67"},"_deposit":{"created_by":18,"id":"51782","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51782"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051782","sets":["2812:2813:3929"]},"author_link":["69343","34"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"15p.","bibliographicVolumeNumber":"2016-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"消化管において栄養物・医薬品の吸収調節に働くトランスポーターに対する食品作用ならびに食品成分の吸収機構に関する検討を行った。本研究では新たに食品ナノ粒子に着目し、ナノ粒子中に含有される高分子が作用するという新しいメカニズムの存在の実証を試みた。その結果、リンゴ等において100nm程度の粒形を有する粒子の存在を確認できた。Caco-2 細胞において本粒子画分は、輸送体分子のmRNAとタンパク質発現量、および活性を低下させた。また、その作用として輸送体遺伝子に対する食品由来マイクロRNAの作用であることを見出した。したがって、食品中の高分子も直接生体に作用する新しいメカニズムを示すことができた","subitem_description_type":"Abstract"},{"subitem_description":"Novel mechanism of food effect on human intestinal function was studied by focusing on microRNA included in food abundantly. By in vitro experiments, apple derived-nanoparticle (APNP) decreased mRNA and protein expression of intestinal transporters. 3’-UTR of transporter gene interacted with APNP. Furthermore, APNP included variable apple-derived microRNA, involvement of microRNA in this down regulation was suggested. Data-base analysis demonstrated that apple microRNA interact with the specific transporter gene. The suggested microRNA downregulated expression of the transporter gene and protein. Accordingly, since microRNA is a large molecule, it was clearly shown that food-derived large molecules such as microRNA directly affect intestinal function through nanoparticle of food, The conclusion also provides new concept of nutrients that food-derived large molecules are directly functional to affect human health.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16H05111, 研究期間(年度):2016-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「輸送体上での食品との相互作用が及ぼす医薬品の動態・作用変動に関する研究」研究成果報告書　課題番号16H05111\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05111/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058085","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20155237"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20155237","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05111/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05111/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"PH-PR-TAMAI-I-kaken 2020-15p.pdf","filesize":[{"value":"576.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-TAMAI-I-kaken 2020-15p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51782/files/PH-PR-TAMAI-I-kaken 2020-15p.pdf"},"version_id":"ee06594f-0548-479e-9589-f90b27f63aa0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"輸送体上での食品との相互作用が及ぼす医薬品の動態・作用変動に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"輸送体上での食品との相互作用が及ぼす医薬品の動態・作用変動に関する研究"},{"subitem_title":"Drug-food interaction on transporters","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-30"},"publish_date":"2021-04-30","publish_status":"0","recid":"51782","relation_version_is_last":true,"title":["輸送体上での食品との相互作用が及ぼす医薬品の動態・作用変動に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:07:08.497787+00:00"}