{"created":"2023-07-27T06:55:46.552987+00:00","id":52018,"links":{},"metadata":{"_buckets":{"deposit":"c0b32bb4-3f36-4241-9cca-d1562ce4dd4b"},"_deposit":{"created_by":18,"id":"52018","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52018"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052018","sets":["2812:2813:4014"]},"author_link":["2401","76693"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2018-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takamatsu, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"76693","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70401932","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70401932"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、抗HLA抗体を産生している患者B細胞と細胞アレイを用いてこれまで作製ができなかった新規抗HLAモノクローナル抗体の作製を行った。これまでに作製に成功した抗HLA-B61とBw4モノクローナル抗体に加えて, A33, B13, B35, B48, B53, B54等のHLA抗原と反応する新規モノクローナル抗体産生遺伝子組換え細胞を作製した。これらのモノクローナル抗体を用いたフローサイトメトリー検査で微小残存病変、同種造血幹細胞移植後のキメリズム解析、免疫抑制療法が奏効しやすい再生不良性貧血の診断が可能になった。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, using peripheral B cells derived from donors and cell-arrays we have created novel monoclonal antibodies that could not be made using conventional methods. In addition to monoclonal antibodies against HLA-B61 and Bw4, we could create recombinant cells that secrete antibodies against HLA-A33, B13, B48, B53 and B54 and so on. Using these novel monoclonal antibodies, we can monitor minimal residual disease, chimerism after allogeneic stem cell transplantation and identify patients with aplastic anemia who respond to immunosuppressive treatments by flow cytometry.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K07293, 研究期間(年度):2018-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「 患者B細胞を用いたモノクローナル抗体作製とその臨床応用」研究成果報告書　課題番号18K07293\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07293/18K07293seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058318","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70401932"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70401932","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07293/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07293/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07293/18K07293seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07293/18K07293seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高松, 博幸"}],"nameIdentifiers":[{"nameIdentifier":"2401","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70401932","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70401932"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-18"}],"displaytype":"detail","filename":"ME-PR-TAKAMATSU-H-kaken 2021-5p.pdf","filesize":[{"value":"75.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKAMATSU-H-kaken 2021-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52018/files/ME-PR-TAKAMATSU-H-kaken 2021-5p.pdf"},"version_id":"152aac22-b4d2-43d5-9a95-e5eb4a8b20a5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"患者B細胞を用いたモノクローナル抗体作製とその臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"患者B細胞を用いたモノクローナル抗体作製とその臨床応用"},{"subitem_title":"Production of monoclonal antibodies using B cells derived from patients and their clinical application","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-18"},"publish_date":"2022-02-18","publish_status":"0","recid":"52018","relation_version_is_last":true,"title":["患者B細胞を用いたモノクローナル抗体作製とその臨床応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:22:14.382164+00:00"}