{"created":"2023-07-27T06:55:46.597457+00:00","id":52021,"links":{},"metadata":{"_buckets":{"deposit":"ec7249d5-3cf5-41f0-aba9-a6982a57ed2f"},"_deposit":{"created_by":18,"id":"52021","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52021"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052021","sets":["2812:2813:4014"]},"author_link":["129","76766"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"15p.","bibliographicVolumeNumber":"2018-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では, 仮説：“老化細胞を除去すると, 原発性胆汁性胆管炎/肝硬変 (PBC)は治る” を検証し, PBCの新しい治療法の開発をめざした。PBCの肝内小型胆管は高率に細胞老化を示すこと,PBCの細胆管細胞における細胞老化は病期, 活動性,標準治療薬：ウルソデオキシコール酸(UDCA)治療不応性に関連することが明らかとなった。さらに,培養細胞を用いた検討では, PBCで発現亢進する細胞老化関連分子Bcl-xLやIFIT3を標的にした薬剤やsiRNAなどによって老化細胞を選択的に除去できることが示された。","subitem_description_type":"Abstract"},{"subitem_description":"The hypothesis: “Removing senescent cells (senolysis) may be a novel effective therapy for primary biliary cholangitis (PBC)” was verified in this study. This study revealed that cellular senescence was frequently observed in biliary epithelial cells in small bile ducts and bile ductules in PBC and that the degree of cellular senescence was associated with the stage and activity of PBC and inadequate response to UDCA. Furthermore, cell culture study disclosed that senescence-associated molecules upregulated in biliary epithelial cells in PBC, such as Bcl-xL and IFIT3, could be novel therapeutic targets by senolytic drugs and siRNA.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K06985, 研究期間(年度):2018-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「老化細胞制御による肝臓病の新しい治療法の開発」研究成果報告書　課題番号18K06985\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（ https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-11770180/ ）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058321","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70225895"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70225895","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06985/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06985/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-18"}],"displaytype":"detail","filename":"ME-PR-SASAKI-M-kaken 2021-15p.pdf","filesize":[{"value":"98.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SASAKI-M-kaken 2021-15p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52021/files/ME-PR-SASAKI-M-kaken 2021-15p.pdf"},"version_id":"c87a8cc9-02d1-459f-a9b2-292b91cc2d3e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"老化細胞制御による肝臓病の新しい治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"老化細胞制御による肝臓病の新しい治療法の開発"},{"subitem_title":"Development of new therapy for liver disease by regulating cellular senescence","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-18"},"publish_date":"2022-02-18","publish_status":"0","recid":"52021","relation_version_is_last":true,"title":["老化細胞制御による肝臓病の新しい治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:49:40.572995+00:00"}