{"created":"2023-07-27T06:55:46.641614+00:00","id":52022,"links":{},"metadata":{"_buckets":{"deposit":"516cc2f4-5152-418e-8336-dcc2d1ba66de"},"_deposit":{"created_by":18,"id":"52022","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52022"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052022","sets":["2812:2813:3929"]},"author_link":["707","23442"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2018-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膜動現象の作動には形質膜や細胞内小胞器官膜の適所におけるグリセロリン脂質ホスホイノシタイド (PPI)の産生と分解が必要である。3’リン酸化PPI合成の律速酵素PI3KにはI-III型の3クラスが存在し、クラスII α型酵素(PI3K-C2α) は、受容体エンドサイトーシスとその後の細胞内受容体シグナリングに必須である。PI3K-C2α、PI3K-C2βの心筋、平滑筋特異的二重KOマウスを作製したところ、心筋特異的二重KOマウスにおいて新生仔は約半数が心不全により生後１～２日以内に死亡し、平滑筋特異的二重KOマウス母親は子宮平滑筋収縮異常による分娩障害を呈した。","subitem_description_type":"Abstract"},{"subitem_description":"Class II phosphoinositide3-kinases (PI3Ks), PI3K-C2α andPI3K-C2β, are highly homologous and distinct from class I and class III PI3Ks in catalytic products and domain structures. In contrast to class I and class III PI3Ks, physiological roles of class II PI3Ks are not fully understood. We studied the phenotypes of cardiomyocyte or smooth muscle–specific knockout (KO) mice of PI3K-C2α and PI3K-C2β. Cardiomyocyte specific PI3K-C2α and PI3K-C2β double KO(DKO) mice show heart failure due to collapse of the sarcomere structure and abnormally mitochondrial accumulation. In smooth muscle–specific KO mice show that the pup numbers from single PI3K- C2α–KO and single PI3K-C2β–KO mothers were similar to those of control, but those from double KO(DKO)mothers were smaller compared with control.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K15010, 研究期間(年度):2018-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「周生期母子生存に必須なPI3キナーゼの新規機能」研究成果報告書　課題番号18K15010\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15010/18K15010seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058322","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80767210"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80767210","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15010/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15010/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15010/18K15010seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15010/18K15010seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"ME-PR-AKI-S-kaken 2020-8p.pdf","filesize":[{"value":"345.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-AKI-S-kaken 2020-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52022/files/ME-PR-AKI-S-kaken 2020-8p.pdf"},"version_id":"7f164f57-3202-40f2-904d-3c615b1ece9b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"周生期母子生存に必須なPI3キナーゼの新規機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"周生期母子生存に必須なPI3キナーゼの新規機能"},{"subitem_title":"New mechanisms of perinatal cardiovascular regulation by class II PI3K","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-30"},"publish_date":"2021-04-30","publish_status":"0","recid":"52022","relation_version_is_last":true,"title":["周生期母子生存に必須なPI3キナーゼの新規機能"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:07:38.056986+00:00"}