{"created":"2023-07-27T06:55:46.910092+00:00","id":52034,"links":{},"metadata":{"_buckets":{"deposit":"cd6a9a4f-34c4-4301-89d8-33d0600d69b6"},"_deposit":{"created_by":18,"id":"52034","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52034"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052034","sets":["2812:2813:4014"]},"author_link":["87","78846"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2018-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"診断と治療の一体化を目指すラジオセラノスティクスにおいて、プローブ開発を効率よく推進することは重要である。一方、アルファ線を用いた治療は、極めて治療効果が高く、世界的に注目されている治療法である。本研究では、アルファ線放出核種として211Atを用いたラジオセラノスティクス確立のための基礎的研究を行った。\nRGDペプチドの新規211At標識法を開発し、211At標識RGDペプチドと125I標識RGDペプチドが、担がんマウスにおいて同等の体内動態を示したことより、ラジオセラノスティクス用プローブとしての有用性が示された。また、211At標識BBN誘導体を作製し、GRPR発現腫瘍への集積を確認した。","subitem_description_type":"Abstract"},{"subitem_description":"Efficient promotion of probe development is important for radiotheranostics, which aims to integrate diagnosis and treatment. On the other hand, the cancer therapy using alpha particles has extremely high therapeutic effects and gathers much attention all over the world. In this study, I conducted a preliminary study to establish radiotheranostics using 211At as an alpha particles emitting radionuclide.\nA novel 211At labeling method for an RGD peptide was developed, and the 211At-labeled RGD peptide and 125I-labeled RGD peptide showed equivalent biodistribution in tumor-bearing mice, demonstrating their usefulness as probes for radiotheranostics. In addition, an 211At-labeled BBN derivative was prepared. It was accumulated in GRPR-expressing tumors.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K07630, 研究期間(年度):2018-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「放射性ハロゲンを用いた包括的癌診断・治療法（ラジオセラノスティクス）の確立」研究成果報告書　課題番号18K07630\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07630/18K07630seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058334","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30347471"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30347471","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07630/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07630/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07630/18K07630seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07630/18K07630seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-21"}],"displaytype":"detail","filename":"FR-PR-OGAWA-K-kaken 2021-9p.pdf","filesize":[{"value":"568.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-OGAWA-K-kaken 2021-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52034/files/FR-PR-OGAWA-K-kaken 2021-9p.pdf"},"version_id":"89dcd8d7-484f-454d-83ec-ed2b961909dd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"放射性ハロゲンを用いた包括的癌診断・治療法（ラジオセラノスティクス）の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射性ハロゲンを用いた包括的癌診断・治療法（ラジオセラノスティクス）の確立"},{"subitem_title":"Establishment of comprehensive cancer diagnosis and therapy using radio halogen","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-21"},"publish_date":"2022-02-21","publish_status":"0","recid":"52034","relation_version_is_last":true,"title":["放射性ハロゲンを用いた包括的癌診断・治療法（ラジオセラノスティクス）の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:49:37.519043+00:00"}