{"created":"2023-07-27T06:55:48.391284+00:00","id":52072,"links":{},"metadata":{"_buckets":{"deposit":"664757a2-e7b4-4317-9ebc-30ddd09ad356"},"_deposit":{"created_by":18,"id":"52072","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52072"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052072","sets":["2812:2813:3929"]},"author_link":["80321","91231"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2018-06-29 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"自閉症発症の原因となる神経細胞種を調べるために、CHD8ヘテロ欠損マウスで脳内の遺伝子発現解析を行ったところ、オリゴデンドロサイト関連遺伝子の発現がもっとも顕著に低下していた。そこで、われわれはオリゴデンドロサイトにおけるCHD8の機能に着目した。CHD8へテロ欠損マウスはミエリン形成の低下やランビエ構造の異常、神経伝導速度の低下などを示した。さらに、オリゴデンドロサイト特異的CHD8へテロ欠損マウスの行動解析を行ったところ、全身CHD8へテロ欠損マウスで観察された行動異常の一部が再現されることが判明した。","subitem_description_type":"Abstract"},{"subitem_description":"Here we show that reduced expression of CHD8 in oligodendrocytes gives rise to abnormal behavioral phenotypes in mice. CHD8 was found to regulate the expression of many myelination-related genes and to be required for oligodendrocyte maturation and myelination. Ablation of Chd8 specifically in oligodendrocytes of mice impaired myelination, slowed action potential propagation, and resulted in behavioral deficits including increased social interaction and anxiety-like behavior, with similar effects being apparent in Chd8 heterozygous mutant mice. Our results thus indicate that CHD8 is essential for myelination and that dysfunction of oligodendrocytes as a result of CHD8 haploinsufficiency gives rise to several neuropsychiatric phenotypes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K19509, 研究期間(年度):2018-06-29 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「自閉症は大人になっても治せるか？」研究成果報告書　課題番号18K19509\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19509/18K19509seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058372","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50423562"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50423562","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19509/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19509/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19509/18K19509seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19509/18K19509seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"ME-PR-NISHIYAMA-M-kaken 2020-8p.pdf","filesize":[{"value":"180.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NISHIYAMA-M-kaken 2020-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52072/files/ME-PR-NISHIYAMA-M-kaken 2020-8p.pdf"},"version_id":"c0505611-a627-4518-91c3-dd46a5a8767e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自閉症は大人になっても治せるか？","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自閉症は大人になっても治せるか？"},{"subitem_title":"Can autism be cured in adulthood?","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-30"},"publish_date":"2021-04-30","publish_status":"0","recid":"52072","relation_version_is_last":true,"title":["自閉症は大人になっても治せるか？"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:08:06.775266+00:00"}