{"created":"2023-07-27T06:55:48.748637+00:00","id":52080,"links":{},"metadata":{"_buckets":{"deposit":"7da69ed1-64e7-450e-9f3e-46cfdf8f0639"},"_deposit":{"created_by":18,"id":"52080","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52080"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052080","sets":["2812:2813:3929"]},"author_link":["2730","76433"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2017-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshimura, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"76433","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20432320","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20432320"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高活性炭素反応種のカルバニオン，ベンザイン，o-キノンメチドを用いる新規不斉反応を開発した。カルバニオンを用いる反応では、ビニルカルバニオンの分子内非対称化によるキラルなビシクロ[4.3.0]ノネン誘導体を中程度の光学純度で合成することができた。ベンザインを経由する反応では，ビフェノール誘導体からビベンザインを発生させフランとの反応を行うことで，ビナフチル化合物の合成が進行することが判明した。今後不斉合成に展開してゆく。o-キノンメチドを経由するクロマン骨格合成は，電子供与性の高いオレフィン基質が重要であることが判明した。","subitem_description_type":"Abstract"},{"subitem_description":"Asymmetric syntheses via highly reactive carbon species, carbanion, benzyne, and o-quinone methide, have been developed. In the reaction via carbanion species, intramolecular desymmetrization of sigma-symmetrical 2-methyl-2-(3'-lithio-2'-propenyl)-1,3-cyclohexandione gave bicyclo[4.3.0]nonene derivative bearing a quaternary carbon stereocenter in 81% yield and up to 39% ee. In the reaction via bibenzyne, it was found that generation of bibenzyne from bis(2-bromophenyl triflate) with n-BuLi occur to give binaphthyl derivatives by treatment with furan. In the reaction via o-quinone methide, it was found that effective synthesis of chromane framework required a suitable olefinic substrate substituted by electron-donating group.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K08208, 研究期間(年度):2017-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「キラルな高活性炭素反応種を用いた四置換炭素含有生理活性天然物の不斉全合成研究」研究成果報告書　課題番号17K08208\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K08208/17K08208seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058380","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20432320"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20432320","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08208/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08208/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K08208/17K08208seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K08208/17K08208seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉村, 智之"}],"nameIdentifiers":[{"nameIdentifier":"2730","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20432320","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20432320"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-10"}],"displaytype":"detail","filename":"PH-PR-YOSHIMURA-T-kaken 2020-8p.pdf","filesize":[{"value":"420.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-YOSHIMURA-T-kaken 2020-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52080/files/PH-PR-YOSHIMURA-T-kaken 2020-8p.pdf"},"version_id":"4cd00a8e-3eef-4d96-952b-898428b48ecb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"キラルな高活性炭素反応種を用いた四置換炭素含有生理活性天然物の不斉全合成研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"キラルな高活性炭素反応種を用いた四置換炭素含有生理活性天然物の不斉全合成研究"},{"subitem_title":"Enantioselective total syntheses of bioactive natural products with tetrasubstituted carbon(s) using highly reactive carbon species","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-10"},"publish_date":"2021-05-10","publish_status":"0","recid":"52080","relation_version_is_last":true,"title":["キラルな高活性炭素反応種を用いた四置換炭素含有生理活性天然物の不斉全合成研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:24:11.517364+00:00"}