{"created":"2023-07-27T06:55:50.354039+00:00","id":52183,"links":{},"metadata":{"_buckets":{"deposit":"44842f54-2e67-42be-b3d8-01aebd366ac6"},"_deposit":{"created_by":18,"id":"52183","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52183"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052183","sets":["2812:2813:4014"]},"author_link":["91198","91199"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2018-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogura, Kohei"}],"nameIdentifiers":[{"nameIdentifier":"91199","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00586612","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00586612"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高齢者への重篤な感染症例が近年になり急増している溶血性レンサ球菌Streptococcus dysgalactiae subsp. equisimilis (SDSE) について、その病原性発揮機構を解析した。SDSEは2型糖尿病モデルマウスに対して高い致死誘導性を示し、その際には血清中での顕著なサイトカイン放出が観察された。また、SDSEは皮膚ヒアルロン酸を分解する酵素を大量に放出することで栄養素として取り込み増殖することで病原性を発揮していた。さらに、流行型のSDSEは、細胞外構造や増殖機構などでそれぞれ固有の性状を有していた。以上より、SDSE固有の病原性発揮メカニズムが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"Streptococcus dysgalactiae subsp. equisimilis (SDSE) causes severe invasive streptococcal infections, especially in elderly people and patients with diabetic mellitus. Although SDSE possesses a genome showing about 70% identity to S. pyogenes's one, it remained unclear how SDSE exhibits pathogenicity. Our purpose in this study was to determine pathogenicity characteristics of SDSE. The survival rates of mice injected with SDSE were significantly lower in mice (db/db) with type 2 diabetes compared with non-diabetic mice. Injection of db/db mice with SDSE increased the concentrations of IL-6. SDSE released dramatically high concentrations of hyaluronate-degrading enzymes (hylauronate lyase). We found the lyase plays important roles in nutrient acquisition from host skins, followed by the bacterial pathogenicity damaging host tissues. We revealed that two prevalent types of SDSE isolates exhibited different characteristics in cell wall structures, anti-phagocytosis, and attachment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K07133 研究期間(年度):2018-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「高病原性レンサ球菌SDSE固有の病原性獲得メカニズム」研究成果報告書　課題番号18K07133\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07133/18K07133seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058480","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00586612"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00586612","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07133/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07133/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07133/18K07133seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07133/18K07133seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小倉, 康平"}],"nameIdentifiers":[{"nameIdentifier":"91198","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00586612","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00586612"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-21"}],"displaytype":"detail","filename":"FR-PR-OGURA-K-kaken 2021-9p.pdf","filesize":[{"value":"328.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-OGURA-K-kaken 2021-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52183/files/FR-PR-OGURA-K-kaken 2021-9p.pdf"},"version_id":"a8cd93be-cfc9-41f6-9c55-910d7f20288f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高病原性レンサ球菌SDSE固有の病原性獲得メカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高病原性レンサ球菌SDSE固有の病原性獲得メカニズム"},{"subitem_title":"How beta-hemolyitc streptocci SDSE exhibits pathogenicity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-21"},"publish_date":"2022-02-21","publish_status":"0","recid":"52183","relation_version_is_last":true,"title":["高病原性レンサ球菌SDSE固有の病原性獲得メカニズム"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:19:27.651335+00:00"}