{"created":"2023-07-27T06:55:52.798629+00:00","id":52328,"links":{},"metadata":{"_buckets":{"deposit":"c15b3482-4764-4896-a152-6aca93d38d73"},"_deposit":{"created_by":18,"id":"52328","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52328"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052328","sets":["2812:2813:2817"]},"author_link":["30555","20582"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトパピローマウイルス（HPV）が関連する難治性の疾患である喉頭乳頭腫の研究モデルを作成するため、培養細胞の樹立を試みた。乳頭腫組織から腫瘍細胞の生着を認めたが、継代することは困難であった。一方、新たな治療の探索のため、腫瘍細胞における免疫染色で、腫瘍のfibrovascular coreにある血管の周囲に血管新生因子である血管内皮増殖因子（VEGF）の発現を確認した。VEGFは血管構造が明らかとなる以前のfibrovascular core様構造箇所に発現していることも確認され、抗VEGF療法の可能性がうかがわれた。","subitem_description_type":"Abstract"},{"subitem_description":"Recurrent respiratory papillomatosis (RRP) is a refractory human papillomavirus (HPV)-associated disease. We tried to establish a tissue culture model of RRP. We confirmed growth of tumor cells in the primary tissue culture. However, continuing growth of those cells could not be achieved in following passage. On the other hand, immunohistochmestry was also performed to investigate a factor for a novel therapy. Expression of vascular endothelial growth factor (VEGF) was observed around fibrovascular cores of RRP. VEGF was observed in cores without an obvious vascular structure. Therefore, anti-VEGF antibody therapy can be a candidate for a novel therapy of RRP.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26462598, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ヒト乳頭腫ウイルスシグナル伝達に着目した喉頭乳頭腫に対する新規治療の開発」研究成果報告書　課題番号26462598\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462598/26462598seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"福島県立医科大学 / 金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058623","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20345622"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20345622","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462598/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462598/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462598/26462598seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462598/26462598seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-09"}],"displaytype":"detail","filename":"ME-PR-MURONO-S-kaken 2017-4p.pdf","filesize":[{"value":"266.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MURONO-S-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52328/files/ME-PR-MURONO-S-kaken 2017-4p.pdf"},"version_id":"1c375b4b-8ef3-4112-a23a-cbe781eafead"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト乳頭腫ウイルスシグナル伝達に着目した喉頭乳頭腫に対する新規治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト乳頭腫ウイルスシグナル伝達に着目した喉頭乳頭腫に対する新規治療の開発"},{"subitem_title":"Therapeutic approach to recurrent respiratory papillomatosis from the perspective of signal transduction of human papillomavirus","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-09"},"publish_date":"2020-07-09","publish_status":"0","recid":"52328","relation_version_is_last":true,"title":["ヒト乳頭腫ウイルスシグナル伝達に着目した喉頭乳頭腫に対する新規治療の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:15:00.607889+00:00"}