{"created":"2023-07-27T06:55:53.754066+00:00","id":52360,"links":{},"metadata":{"_buckets":{"deposit":"06fe5d48-dec2-498a-9f98-fbdb9e34affc"},"_deposit":{"created_by":18,"id":"52360","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52360"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052360","sets":["2812:2813:2822"]},"author_link":["109"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009 – 2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"リソソームに局在するプロテアーゼであるアスパラギンエンドペプチダーゼ(AEP)を欠損するマウスの骨髄には,リソソーム病であるゴーシェ病に出現するゴーシェ細胞様の血球貪食細胞が蓄積することから, AEP欠損マウスをリソソーム病を自然発症する新規動物モデルとして位置づけ,その特徴付けを行った。遺伝子発現解析は老化赤血球の排除機構亢進を示唆するものの培養系に移すと再現しないが,病態発症初期における骨髄局所におけるマクロファージの分化・増殖状態の異常が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Asparagine endopeptidase(AEP) is a lysosomal cysteine protease. We have characterized AEP-deficient mice as a disease model of human hemomphagocytic syndrome, which developed hemophagocytosis especially in bone marrow. A part of hemophagpocytes resembled Gaucher cells in Gaucher disease, one of lysosomal storage disease. We have conducted further examinations so as to characterize AEP-deficient mice as a new model of lysosomal disease.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21500387, 研究期間(年度):2009 – 2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「血球貪食症候を主徴とするリソソーム病の新規病態モデルの確立」課題番号21500387\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21500387/21500387seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058654","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50242524"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50242524","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21500387/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21500387/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21500387/21500387seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21500387/21500387seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-06"}],"displaytype":"detail","filename":"LAB-PR-HASHIMOTO-N-kaken 2012-5p.pdf","filesize":[{"value":"433.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"LAB-PR-HASHIMOTO-N-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52360/files/LAB-PR-HASHIMOTO-N-kaken 2012-5p.pdf"},"version_id":"5392e2f5-f9ab-4742-b078-865b0fa513d7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血球貪食症候を主徴とするリソソーム病の新規病態モデルの確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血球貪食症候を主徴とするリソソーム病の新規病態モデルの確立"},{"subitem_title":"Characterization of AEP/Legumain-deficient mice as a new model of lysosome disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-06"},"publish_date":"2020-07-06","publish_status":"0","recid":"52360","relation_version_is_last":true,"title":["血球貪食症候を主徴とするリソソーム病の新規病態モデルの確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:25:11.569711+00:00"}