{"created":"2023-07-27T06:55:55.590303+00:00","id":52409,"links":{},"metadata":{"_buckets":{"deposit":"32a99deb-d6ee-44f9-8f41-c19aad3ebac8"},"_deposit":{"created_by":18,"id":"52409","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52409"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052409","sets":["2812:2813:2815"]},"author_link":["93682"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"足場非依存性増殖はがん細胞に特徴的であり有望な治療標的と考えられるが、そのメカニズムの全容は未だ不明である。そこで、足場非依存性増殖に関わる分子Xに着目し、分子Xの生体における役割、特にがん進展における役割の解明を目指した。ノックアウトマウスの解析により、分子Xはがん細胞だけでなく腫瘍免疫抑制細胞にも発現しその数を増加させていることが分かった。また、乳がんモデルマウスを用いた解析から、分子Xは個体レベルでのがんの増殖と転移を促進することが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"Anchorage-independent growth is characteristic for cancer cells, but the perspective of its regulatory mechanisms remains unclear. To address this, we focused on the molecule X which has been reported to control anchorage independent growth of cancer cells in vitro and tried to clarify the role of molecule X in vivo, especially in tumor progression. The analyses of X knockout mice revealed that molecule X expressed not only in cancer cells but also in host imuunesuppressive cells and increased the number of immunesuppressive cells. The molecule X also promoted tumor growth and lung metastasis in breast cancer model mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K06829, 研究期間(年度):2015-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「がん進展における代謝を介した足場非依存性増殖制御の役割」課題番号15K06829\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K06829/15K06829seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 東京大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058703","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70511418"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70511418","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K06829/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K06829/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K06829/15K06829seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K06829/15K06829seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-17"}],"displaytype":"detail","filename":"ME-PR-SAKAMOTO-T-kaken 2019-6p.pdf","filesize":[{"value":"210.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAKAMOTO-T-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52409/files/ME-PR-SAKAMOTO-T-kaken 2019-6p.pdf"},"version_id":"513bab9f-648b-42a3-901f-23fa6c38f1de"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん進展における代謝を介した足場非依存性増殖制御の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん進展における代謝を介した足場非依存性増殖制御の役割"},{"subitem_title":"Role of anchorage-independent growth regulation in tumor progression","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-17"},"publish_date":"2020-07-17","publish_status":"0","recid":"52409","relation_version_is_last":true,"title":["がん進展における代謝を介した足場非依存性増殖制御の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:30:40.206025+00:00"}