{"created":"2023-07-27T06:55:55.871265+00:00","id":52419,"links":{},"metadata":{"_buckets":{"deposit":"a0323ef8-0cc9-458c-ad0e-d33463e65a88"},"_deposit":{"created_by":18,"id":"52419","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52419"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052419","sets":["2812:2813:2822"]},"author_link":["93682","24979"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010 – 2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"解糖系は癌や炎症性疾患などで重要な役割を果たすエネルギー産生機構であるが、その制御機構は未だ不明な点が多い。そこで本研究では、ゲノムワイドsiRNAライブラリーを用いて解糖系制御に関わる遺伝子を探索し、新規に解糖系制御に関わる遺伝子を19個同定した。これらの遺伝子の中には、その遺伝子発現を抑制することで癌細胞の増殖を抑えるものや、マクロファージの機能を抑制するものが見られた。これらの新規遺伝子は、解糖系制御を介して癌、炎症性疾患などの疾患の新たな治療標的になるかもしれない。","subitem_description_type":"Abstract"},{"subitem_description":"Glycolysis is a system of energy production which plays an important role in many diseases such as cancer and inflammatory diseases. However, how glycolysis is regulated remains unclear. To address this, we explored novel genes that regulate glycolysis using a genome-wide siRNA library, and identified novel 19 genes. Some of these genes regulate cancer cell growth or macrophage function. Therefore, these genes we identified in this study might be therapeutic targets for cancer or inflammatory diseases.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22790846, 研究期間(年度):2010 – 2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ゲノムワイドsiRNAライブラリーを用いた新規解糖系制御遺伝子探索と疾患への応用」課題番号22790846\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22790846/22790846seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 東京大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058713","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70511418"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70511418","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22790846/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22790846/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22790846/22790846seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22790846/22790846seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-17"}],"displaytype":"detail","filename":"ME-PR-SAKAMOTO-T-kaken 2012-4p.pdf","filesize":[{"value":"264.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAKAMOTO-T-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52419/files/ME-PR-SAKAMOTO-T-kaken 2012-4p.pdf"},"version_id":"3fe588fd-fb74-47be-beb5-7bbac9ecc675"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ゲノムワイドsiRNAライブラリーを用いた新規解糖系制御遺伝子探索と疾患への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ゲノムワイドsiRNAライブラリーを用いた新規解糖系制御遺伝子探索と疾患への応用"},{"subitem_title":"Exploring novel genes that regulate glycolysis using a genome-wide siRNA library","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-17"},"publish_date":"2020-07-17","publish_status":"0","recid":"52419","relation_version_is_last":true,"title":["ゲノムワイドsiRNAライブラリーを用いた新規解糖系制御遺伝子探索と疾患への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:25:13.005329+00:00"}