{"created":"2023-07-27T06:55:55.969442+00:00","id":52421,"links":{},"metadata":{"_buckets":{"deposit":"4a9f0216-9d34-4ac8-a216-82564fcb9b84"},"_deposit":{"created_by":18,"id":"52421","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52421"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052421","sets":["2812:2813:2823"]},"author_link":["93683"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009 – 2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"薬物の消化管吸収・排泄に働くinfluxおよびeffluxトランスポーターの薬物への作用を定量的に解析したところ、talinolol、pravastatinおよびpitavastatinなど様々な薬物の消化管吸収にOatpが関与している可能性が示され、さらにOatpによるそれらの輸送がP-gpにより相殺される可能性が示された。本研究成果によって、より精度の高い薬物吸収性評価法を提唱するにあたり、これら両タイプのトランスポーター活性に対する優位性・相殺性を組み込むことの重要性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"In the present study, we aimed to clarify the contribution of OATP/Oatp and P-gp to the intestinal absorption of various drugs by means of various in vitro, in situ and in vivo experimental techniques. Trough the studies with various drugs including talinolol and pravastatin, pitavastatin, finally, this study revealed that OATP/Oatp is involved in intestinal drug absorption and the contribution of OATP/Oatp-mediated uptake was apparently attenuated by P-gp-mediated efflux in intestinal drug absorption process.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21790147, 研究期間(年度):2009 – 2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「吸収/排泄型トランスポーターの相殺性に基づく薬物吸収動態予測」課題番号21790147\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21790147/21790147seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058715","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60453833"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60453833","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21790147/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21790147/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21790147/21790147seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-21790147/21790147seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-17"}],"displaytype":"detail","filename":"PH-PR-SHIRASAKA-Y-kaken 2011-4p.pdf","filesize":[{"value":"194.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-SHIRASAKA-Y-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52421/files/PH-PR-SHIRASAKA-Y-kaken 2011-4p.pdf"},"version_id":"e10f25b5-33fd-4f1d-8e09-dc4f90402543"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"吸収/排泄型トランスポーターの相殺性に基づく薬物吸収動態予測","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"吸収/排泄型トランスポーターの相殺性に基づく薬物吸収動態予測"},{"subitem_title":"Quantitative Evaluation of the Effect of Influx/Efflux Transporters on Oral Drug Absorption","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-17"},"publish_date":"2020-07-17","publish_status":"0","recid":"52421","relation_version_is_last":true,"title":["吸収/排泄型トランスポーターの相殺性に基づく薬物吸収動態予測"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:22:24.862977+00:00"}