{"created":"2023-07-27T06:55:56.294802+00:00","id":52428,"links":{},"metadata":{"_buckets":{"deposit":"bab1ee54-98ca-464d-8695-d35990ccfaba"},"_deposit":{"created_by":18,"id":"52428","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52428"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052428","sets":["2812:2813:3929"]},"author_link":["74806","75023"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2017-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ゼブラフィッシュを用いた研究において、ミトコンドリア関連因子であるUSMG5(Up-regulated during skeletal muscle growth protein 5)の遺伝子発現を阻害することにより、心不全が誘導された。マウス心筋細胞を用いたUSMG5阻害実験では、網羅的遺伝子発現解析においてアポトーシスに関連する遺伝子などの発現に影響を与えていた。さらに、細胞内でのシグナル伝達を検討したところ、JNKリン酸化に関与していることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Heart failure was induced by inhibiting gene expression of z-usmg5(Up-regulated during skeletal muscle growth protein 5) in zebrafish which was a mitochondrial factor. Inhibition of USMG5 gene expression affected the expression of genes in conjunction with the apoptosis in the comprehensive gene analysis using a neonatal mouse cardiomyocyte. Furthermore, it demonstrated that USMG5 have relation to JNK phosphorylation in a pathway analysis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K15995, 研究期間(年度):2017-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「新規ミトコンドリア関連分子USMG5が拡張型心筋症の発症進展に与える機序の解明」研究成果報告書　課題番号17K15995\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K15995/17K15995seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058722","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50632478"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50632478","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K15995/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K15995/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K15995/17K15995seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K15995/17K15995seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-10"}],"displaytype":"detail","filename":"ME-PR-NAGATA-Y-kaken 2020-6p.pdf","filesize":[{"value":"318.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAGATA-Y-kaken 2020-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52428/files/ME-PR-NAGATA-Y-kaken 2020-6p.pdf"},"version_id":"3f4ec021-983c-4f27-b8d4-6b0e6f41bc5a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規ミトコンドリア関連分子USMG5が拡張型心筋症の発症進展に与える機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規ミトコンドリア関連分子USMG5が拡張型心筋症の発症進展に与える機序の解明"},{"subitem_title":"Heart Failure Phenotypes Induced by Knockdown of USMG5 in Zebrafish: A New Insight Into Mechanism of Dilated Cardiomyopathy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-10"},"publish_date":"2021-05-10","publish_status":"0","recid":"52428","relation_version_is_last":true,"title":["新規ミトコンドリア関連分子USMG5が拡張型心筋症の発症進展に与える機序の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:09:06.975402+00:00"}