{"created":"2023-07-27T06:55:56.836903+00:00","id":52447,"links":{},"metadata":{"_buckets":{"deposit":"7950cb61-4c25-4beb-a090-cd89b8d0c22d"},"_deposit":{"created_by":18,"id":"52447","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52447"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052447","sets":["2812:2813:3929"]},"author_link":["2996"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2018-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nonaka, Saori"}],"nameIdentifiers":[{"nameIdentifier":"2996","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40767787","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40767787"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ショウジョウバエにおいて、Tollの新規内因性リガンドSpz5は、既知のTollリガンドSpzとは異なり、プロテアーゼによる切断を受けずにTollリガンドとして働くこと、Spz5-Tollの下流ではdMyd88が情報伝達分子として働くことがわかった。しかし、当初の予想に反して、ショウジョウバエ幼虫をピンセットでつまむと抗菌ペプチドが産生されるという申請者のグループが独自に開発した感染非依存の免疫の異常活性化のモデル系へのSpz5の関与は示せず、感染非依存の免疫活性化機構の全容は解明はできなかった。その代わりに、Spz5はSpzと協調して、ショウジョウバエの正常な個体発生に働くことが示された。","subitem_description_type":"Abstract"},{"subitem_description":"We demostrated that Spz5 works as a Toll ligand without clevage by protease in Drosophila although Spz, a famous Toll ligand, needs activation by protease. And, dMyd88 was identified as a signal transducer in the downstream of Spz5-Toll. However, we couldn't show the requirement of Spz5 in infection-independent expression of antimicrobial peptides in larvae after pinching, and the mechanism of infection-independenet immunity remains unclear. Instead of that, we showed genetic interaction between Spz5 and Spz in the developmental process of Drosophila.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K15181, 研究期間(年度):2018-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「新規内因性リガンドによる感染非依存の免疫活性化機構の解析」研究成果報告書　課題番号18K15181\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15181/18K15181seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系 / 安田女子大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058741","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=40767787"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=40767787","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K15181/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K15181/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15181/18K15181seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15181/18K15181seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野中, さおり"}],"nameIdentifiers":[{"nameIdentifier":"2996","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40767787","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40767787"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-10"}],"displaytype":"detail","filename":"PH-PR-NONAKA-S-kaken 2020-4p.pdf","filesize":[{"value":"78.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NONAKA-S-kaken 2020-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52447/files/PH-PR-NONAKA-S-kaken 2020-4p.pdf"},"version_id":"490be8af-c265-4548-9d2c-516b5f87dbea"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規内因性リガンドによる感染非依存の免疫活性化機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規内因性リガンドによる感染非依存の免疫活性化機構の解析"},{"subitem_title":"Infection-independent immunity mediated by a novel endogenious Toll ligand Spz5","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-10"},"publish_date":"2021-05-10","publish_status":"0","recid":"52447","relation_version_is_last":true,"title":["新規内因性リガンドによる感染非依存の免疫活性化機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:24:15.493847+00:00"}