{"created":"2023-07-27T06:55:57.109450+00:00","id":52454,"links":{},"metadata":{"_buckets":{"deposit":"09b2682a-1e52-49bc-a8c6-5823021ce0cb"},"_deposit":{"created_by":18,"id":"52454","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52454"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052454","sets":["2812:2813:3929"]},"author_link":["2944"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2018-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"薬物治療において、期待される薬効や副作用には大きな個人差が認められ、その個人差は、肝臓に発現するシトクロムP450などの薬物代謝酵素の活性や発現量の差による場合が多い。本研究では、薬物代謝酵素の発現を制御することが知られている核内受容体であるpregnane X receptor (PXR) とconstitutive androstane receptor (CAR) の発現が、転写後塩基置換であるA-to-I RNA編集によって制御されることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Adenosine deaminases acting on RNA (ADAR) 1 and ADAR2 enzymes-catalyzing A-to-I RNA editing possibly modulates gene expression and function. In this study, we found that ADAR regulate the expression of human　pregnane X receptor and constitutive androstane receptor, which controls the expression of various drug-metabolizing enzymes. RNA editing enzymes ADAR1 and ADAR2 would be novel regulatory factors of drug metabolism potencies in the human liver.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K14901, 研究期間(年度):2018-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「薬物動態制御因子PXRおよびCARの発現に与えるRNA編集の影響」研究成果報告書　課題番号18K14901\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K14901/18K14901seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058748","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00816225"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00816225","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K14901/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K14901/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K14901/18K14901seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K14901/18K14901seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-10"}],"displaytype":"detail","filename":"PH-PR-NAKANO-M-kaken 2020-9p.pdf","filesize":[{"value":"274.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKANO-M-kaken 2020-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52454/files/PH-PR-NAKANO-M-kaken 2020-9p.pdf"},"version_id":"322e6062-6803-4ea6-9c39-ec5389ca31c3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"薬物動態制御因子PXRおよびCARの発現に与えるRNA編集の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬物動態制御因子PXRおよびCARの発現に与えるRNA編集の影響"},{"subitem_title":"RNA editing-mediated regulation of PXR and CAR","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-10"},"publish_date":"2021-05-10","publish_status":"0","recid":"52454","relation_version_is_last":true,"title":["薬物動態制御因子PXRおよびCARの発現に与えるRNA編集の影響"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:09:11.516290+00:00"}