{"created":"2023-07-27T06:55:58.628184+00:00","id":52491,"links":{},"metadata":{"_buckets":{"deposit":"8a0c5eea-2ece-4259-aa62-45fe5406e3ef"},"_deposit":{"created_by":18,"id":"52491","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52491"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052491","sets":["2812:2813:2815"]},"author_link":["2874"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2017-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膠芽腫細胞株及び膠芽腫幹細胞株においてEphB4シグナルは遊走能、浸潤能を有意に抑制した。細胞表現型の変化とAktリン酸化に相関関係を認めた。EphB4は腫瘍内部でのみ確認され浸潤膠芽腫細胞では確認できなかった。これより腫瘍細胞密度の高い腫瘍内部ではephrin-B2によるEphB4シグナルがAktの脱リン酸化を介してグリオーマ細胞の遊走能、浸潤能を抑制することが示唆された。一方、腫瘍と正常脳の境界ではEphB4による細胞停留シグナルが解除されると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"EphB4 was highly expressed in glioma cell lines and glioma stem cell lines. EphB4 phosphorylation by ephrin-B2 suppressed migration and invasion and downregulation of EphB4 using small interfering RNA negated the suppression of migration and invasion induced by ephrin-B2. Stimulation of glioma cells with ephrin-B2 reduced the phosphorylated Akt levels dose dependently, which was abrogated by siRNA for EphB4. EphB4-positive cells existed only at the tumor core, whereas Ephrin-B2-positive cells existed both at invasive area and the tumor core. Ligand dependent EphB4 signaling plays a role as “stay there” signaling. Extinction of its signaling promotes the release of tumor cell on its location.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K16636, 研究期間(年度):2017-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「膠芽腫細胞株におけるEphB4受容体のシグナル解析及び前臨床試験」課題番号17K16636\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K16636/17K16636seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058785","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80646688"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80646688","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K16636/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K16636/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K16636/17K16636seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K16636/17K16636seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-27"}],"displaytype":"detail","filename":"ME-PR-KAWAHARA-Y-kaken 2019-4p.pdf","filesize":[{"value":"529.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KAWAHARA-Y-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52491/files/ME-PR-KAWAHARA-Y-kaken 2019-4p.pdf"},"version_id":"5209ecd5-b157-4590-a5a6-79f80795bdb1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膠芽腫細胞株におけるEphB4受容体のシグナル解析及び前臨床試験","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膠芽腫細胞株におけるEphB4受容体のシグナル解析及び前臨床試験"},{"subitem_title":"Activation of Ligand-dependent EphB4 signal in glioma cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-27"},"publish_date":"2020-07-27","publish_status":"0","recid":"52491","relation_version_is_last":true,"title":["膠芽腫細胞株におけるEphB4受容体のシグナル解析及び前臨床試験"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:30:45.674759+00:00"}