{"created":"2023-07-27T06:55:58.763917+00:00","id":52494,"links":{},"metadata":{"_buckets":{"deposit":"094c6288-b3b3-4161-9353-a7f259a3c2b1"},"_deposit":{"created_by":18,"id":"52494","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52494"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052494","sets":["2812:2813:3929"]},"author_link":["10306","93697"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2018-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトなどの高等哺乳動物にある大脳皮質の脳回は、大脳皮質の拡大と高次脳機能の獲得に重要と考えられるが、脳回形成の分子機構はほとんど明らかになっていない。本研究課題では、脳回形成における内在的なFGFシグナルの重要性を検証した。フェレットの大脳皮質に優性不能型FGF受容体を発現させた結果、脳回形成が阻害された。組織レベルでの解析を行った結果、優性不能型FGF受容体により高等哺乳動物に特徴的な神経前駆細胞(oRG)が減少していた。これらの結果は、FGFがoRGの分裂を促進し、その結果として脳回が生じるとの仮説を支持している。我々の研究技術は、高等哺乳動物に特徴的な様々な脳構築の解析に有用である。","subitem_description_type":"Abstract"},{"subitem_description":"The gyrus of the cerebral cortex found in higher mammals, such as humans, is thought to be important for cortical expansion and acquisition of higher brain functions. However, the molecular mechanisms of gyrus formation are still unclear. In this study, we examined the role of intrinsic FGF signaling in gyrus formation. Introduction of a dominant-negative FGF receptor in the ferret cerebral cortex markedly inhibited gyrus formation. Histological analyses showed that the dominant-negative FGF receptor reduced oRG cells. These results support the hypothesis that FGF promotes oRG cell proliferation, resulting in the formation of the gyrus. Our research techniques are useful for analyzing the various brain structures characteristic of higher mammals.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K14812, 研究期間(年度):2018-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「大脳皮質の脳回形成を司る分子シグナル経路の解明」研究成果報告書　課題番号18K14812\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K14812/18K14812seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058788","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20774756"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20774756","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K14812/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K14812/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K14812/18K14812seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K14812/18K14812seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"ME-PR-MATSUMOTO-N-kaken 2020-5p.pdf","filesize":[{"value":"327.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MATSUMOTO-N-kaken 2020-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52494/files/ME-PR-MATSUMOTO-N-kaken 2020-5p.pdf"},"version_id":"2a4cc4e6-3678-484e-a8fb-c43c444a39fd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大脳皮質の脳回形成を司る分子シグナル経路の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大脳皮質の脳回形成を司る分子シグナル経路の解明"},{"subitem_title":"Molecular mechanisms underlying the folding of the cerebral cortex","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"52494","relation_version_is_last":true,"title":["大脳皮質の脳回形成を司る分子シグナル経路の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:09:12.852902+00:00"}