{"created":"2023-07-27T06:55:58.943540+00:00","id":52498,"links":{},"metadata":{"_buckets":{"deposit":"739864c6-24ce-40dc-8a22-fa61bf82fa7e"},"_deposit":{"created_by":18,"id":"52498","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52498"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052498","sets":["2812:2813:3929"]},"author_link":["93698","24016"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2018-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"C型肝炎ウイルス排除達成（SVR）群とSVR後肝癌群の網羅的メチル化解析、および発現量解析にて今回TMEMを同定した。TMEMは新規かつ機能未知の遺伝子である。TMEMは腫瘍浸潤血管内皮細胞に発現が見られ、TMEM高発現群で有意に肝癌無再発期間が短期であった。TMEM過剰発現血管内皮細胞は、腫瘍形成を有意に亢進することが確認できた。TMEMは、ERストレス経路を介して腫瘍形成を亢進することが示された。TMEMは、肝発がん及び肝細胞癌の治療標的になり得ることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We identified TMEM this time by comprehensive methylation analysis of the group achieving sustained viral response (SVR) and HCC group after achieving SVR, and expression level analysis. TMEM is a novel gene of unknown function. TMEM was found to be expressed in tumor-infiltrating vascular endothelial cells, and the recurrence-free period of liver cancer was significantly short in the high TMEM-expressing group. It was confirmed that TMEM-overexpressing vascular endothelial cells significantly promote tumor formation. TMEM has been shown to enhance tumorigenesis via the ER stress pathway. It was suggested that TMEM could be a therapeutic target for liver carcinogenesis and hepatocellular carcinoma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K15777, 研究期間(年度):2018-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「血管内皮細胞が肝発がん・再発に関わるメカニズムの解明」研究成果報告書　課題番号18K15777\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"独立行政法人国立病院機構 / 金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058792","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90794511"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90794511","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K15777/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K15777/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"HO-PR-NISHIKAWA-M-kaken 2020-4p.pdf","filesize":[{"value":"244.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-NISHIKAWA-M-kaken 2020-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52498/files/HO-PR-NISHIKAWA-M-kaken 2020-4p.pdf"},"version_id":"53b1ddc8-a17d-4f08-832b-d0be3e644ea5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血管内皮細胞が肝発がん・再発に関わるメカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血管内皮細胞が肝発がん・再発に関わるメカニズムの解明"},{"subitem_title":"Elucidation of the mechanism by which vascular endothelial cells are involved in liver carcinogenesis/recurrence","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"52498","relation_version_is_last":true,"title":["血管内皮細胞が肝発がん・再発に関わるメカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:09:14.209544+00:00"}