{"created":"2023-07-27T06:55:59.077904+00:00","id":52502,"links":{},"metadata":{"_buckets":{"deposit":"f0ea14a1-de2b-490c-adb7-dc655986f55c"},"_deposit":{"created_by":18,"id":"52502","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52502"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052502","sets":["2812:2813:3929"]},"author_link":["24499","67785"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2018-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は以下の 4研究項目のもとに、EMTが誘導する 4D 型高浸潤口腔癌細胞や癌関連線維芽細胞の形成過程で発現低下する MMPを調べた。さらに、PD-L1 を分解する MMP を特定し、既存の抗がん剤のなかからこのMMP発現を上昇させるものを同定した。１、EMTが誘導する4D型高浸潤口腔癌や癌関連線維芽細胞の形成過程で発現低下するMMPの特定。２、EMTの誘導により4D型高浸潤口腔癌や癌関連線維芽細胞で発現低下するMMPのPD-L1分解活性の検討\n３、PD-L1のMMPによる切断活性の検討。４、PD-L1の分解活性を持つMMPを発現上昇させる抗がん剤の検討","subitem_description_type":"Abstract"},{"subitem_description":"Based on the following four study items, this study investigated MMPs that are reduced in EMT-induced formation of 4D type highly invasive oral cancer cells and cancer-associated fibroblasts. In addition, MMP which degrades PD-L1 was identified, and among the existing anticancer drugs, those which elevate this MMPs expression were identified. 1, Identification of MMPs that are reduced during EMT-induced formation of type 4D highly invasive oral cancers and cancer-associated fibroblasts. 2, Examination of PD-L1 degradation activity of MMPs, which are decreased in 4D type highly invasive oral cancer and cancer-associated fibroblasts by inducing EMTs. 3, Examination of the cleavage activity of PD-L1 by MMPs. 4, Investigation of anticancer drugs that increase the expression of MMPs with degradative activity of PD-L1.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K17221, 研究期間(年度):2018-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「高転移性高浸潤性口腔癌の微小環境での腫瘍免疫調節機構の解明」研究成果報告書　課題番号18K17221\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K17221/18K17221seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058796","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=40802830"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=40802830","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K17221/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K17221/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K17221/18K17221seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K17221/18K17221seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"ME-PR-HIRAI-M-kaken 2020-4p.pdf","filesize":[{"value":"75.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HIRAI-M-kaken 2020-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52502/files/ME-PR-HIRAI-M-kaken 2020-4p.pdf"},"version_id":"8d1cdaa5-0a0b-4140-93f6-42d0051f8073"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高転移性高浸潤性口腔癌の微小環境での腫瘍免疫調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高転移性高浸潤性口腔癌の微小環境での腫瘍免疫調節機構の解明"},{"subitem_title":"Analysis of tumor immunomodulatory mechanisms in the microenvironment of highly metastatic, highly invasive oral cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"52502","relation_version_is_last":true,"title":["高転移性高浸潤性口腔癌の微小環境での腫瘍免疫調節機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:09:15.618692+00:00"}