{"created":"2023-07-27T06:56:00.365713+00:00","id":52536,"links":{},"metadata":{"_buckets":{"deposit":"dd6f9197-3afb-4039-8f07-b7c89fa69bba"},"_deposit":{"created_by":18,"id":"52536","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52536"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052536","sets":["2812:2813:2820"]},"author_link":["93712"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wong, W. R."}],"nameIdentifiers":[{"nameIdentifier":"93712","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30464035","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30464035"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"真核細胞の核膜孔を形成する核膜孔複合体(NPC)は、30種類以上のNPCタンパク質で構成されており、核―細胞質間のRNA、及びタンパク質の輸送を制御している。申請者らは、NPCタンパク質であるRae1、及びNup98が白血病発症に関与することを発見した。NPCタンパク質は重要な転写因子の輸送、及び有糸分裂期での機能を持っているため、申請者はNPCタンパク質が白血病発症の際にエピジェネティックを解析することを目的とした。\n申請者はNup98/JARID1Aトランスジェニックマウスの樹立に成功した。現在、引き続き白血病発症メカニズムの解析を行っている。","subitem_description_type":"Abstract"},{"subitem_description":"Nuclear pore complexes are embedded in the nuclear envelope and act as molecular sieves, selectively facilitating the transport of proteins and RNA in and out of the nucleus. Recently, we showed that NUP98 binding partner, RAE1 involved in the development of NUP98-HOXA9 leukemogenesis. We want to investigate epigenetic mechanism in carcinogenesis through a novel approach of nucleoporins-histone modifiers orchestration. We also plan to compare the difference between the difference of NUP98 fusions, HOX genes (NUP98-HOXA9) and those fusions with PHD domain (NUP98-JARID1A). Through this grant support, we have generated NUP98-JARID1A mice. We are still investigating the NUP98-JARID1A and the leukemogenesis via this mice. Meanwhile, we also published several related NPC papers and presented some of our data in the international and domestic conferences.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24650611, 研究期間(年度):2012-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「核膜孔複合体タンパク質の発現異常による白血病の分子機構の解析」研究成果報告書　課題番号24650611\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24650611/24650611seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058830","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=30464035"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=30464035","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24650611/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24650611/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24650611/24650611seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24650611/24650611seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wong, Wung Chuen Richard"}],"nameIdentifiers":[{"nameIdentifier":"93712","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30464035","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30464035"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-30"}],"displaytype":"detail","filename":"FR-PR-WONG-W-R-kaken 2014-4p.pdf","filesize":[{"value":"308.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-WONG-W-R-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52536/files/FR-PR-WONG-W-R-kaken 2014-4p.pdf"},"version_id":"40fe1c3e-21ff-41b1-b424-af9d9a6a4d16"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"核膜孔複合体タンパク質の発現異常による白血病の分子機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"核膜孔複合体タンパク質の発現異常による白血病の分子機構の解析"},{"subitem_title":"The molecular mechanism of nuclear pore proteins and leukemogenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-30"},"publish_date":"2020-07-30","publish_status":"0","recid":"52536","relation_version_is_last":true,"title":["核膜孔複合体タンパク質の発現異常による白血病の分子機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:52:52.311113+00:00"}