{"created":"2023-07-27T06:56:01.031558+00:00","id":52550,"links":{},"metadata":{"_buckets":{"deposit":"f83801e9-ca09-4bd2-a1e6-18d9f5e088a2"},"_deposit":{"created_by":18,"id":"52550","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52550"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052550","sets":["2812:2813:3929"]},"author_link":["93932"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2018-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iizuka, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"93932","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90748617","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90748617"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"先行研究で子宮頸部異形成とAPOBEC3の発現に相関があることが示唆されていた。本研究では、子宮頸部への感染や炎症とAPOBEC3の発現とを培養細胞を用いて検討した。自然免疫機構としてインターフェロンやトル様受容体9のリガンドを用いた検討でAPOBEC3Aの発現が上昇することが分かった。この発現はインターフェロンとトル様受容体9のリガンドで相乗作用を示すことが示唆された。またAPOBEC3の作用により細胞内のHPV-DNAの高頻度突然変異が生じることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Previous studies have suggested association between cervical dysplasia and APOBEC3 expression. In the present study, cervical infection and APOBEC3 expression were examined using cultured cells. The expression of APOBEC3A was found to be up-regulated in studies using interferon and toll-like receptor 9 ligands as innate immune mechanisms. This expression was suggested to be synergistic with the ligands of interferon and tor-like receptor 9.\nIn addition, the action of these molecules may result in hype- mutations of HPV-DNA in cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K16792, 研究期間(年度):2018-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「感染によるAPOBEC発現を介した遺伝子変異誘導とCIN進行機構の解明」研究成果報告書　課題番号18K16792\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K16792/18K16792seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058844","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90748617"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90748617","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K16792/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K16792/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K16792/18K16792seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K16792/18K16792seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"飯塚, 崇"}],"nameIdentifiers":[{"nameIdentifier":"93932","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90748617","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90748617"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"ME-PR-IIZUKA-T-kaken 2020-4p.pdf","filesize":[{"value":"410.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-IIZUKA-T-kaken 2020-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52550/files/ME-PR-IIZUKA-T-kaken 2020-4p.pdf"},"version_id":"e3175f76-d91e-4d8e-aba7-42a5cae41416"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"感染によるAPOBEC発現を介した遺伝子変異誘導とCIN進行機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"感染によるAPOBEC発現を介した遺伝子変異誘導とCIN進行機構の解明"},{"subitem_title":"APOBEC-mediated gene mutagenesis and mechanism of CIN progression induced by infection","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"52550","relation_version_is_last":true,"title":["感染によるAPOBEC発現を介した遺伝子変異誘導とCIN進行機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:25:20.018566+00:00"}