{"created":"2023-07-27T06:56:01.709845+00:00","id":52579,"links":{},"metadata":{"_buckets":{"deposit":"da56c3cd-1f33-44c6-b760-fb40dcba3a83"},"_deposit":{"created_by":18,"id":"52579","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52579"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052579","sets":["2812:2813:4085"]},"author_link":["94239","45621"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2020-04-01 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hematopoietic stem cell transplantation, the curative treatment for refractory hematopoietic malignancies such as leukemia, could develop serious complication including Graft-Versus-Host-Disease (GVHD). Recombinant thrombomodulin, the drug for DIC developed in japan, had been proven to prevent Sclerodermatous chronig GVHD in the rodent models.\nIts mechanism was not the suppression of systemic or local inflammatory cells and cytokines, which had already been clarified as the pathogenic mechanism of chronic GVHD. The pathogenesis of chronic GVHD was thought to involve an unknown inflammatory mechanism that could be controlled by recombinant thrombomodulin.","subitem_description_type":"Abstract"},{"subitem_description":"造血幹細胞移植は、白血病などの難治性造血器腫瘍の根治的治療法であるが、重篤な合併症である移植片対宿主病(Graft-Versus-Host-Disease: GVHD)を伴う。申請者は、マウスを用いた移植実験で、日本発の画期的なDIC治療薬であるリコモジュリンが皮膚慢性GVHDを抑制できることを証明した。その作用機序は、慢性GVHD発症機序として既に明らかとなっている全身や皮膚局所の炎症細胞・サイトカインの抑制ではなかった。慢性GVHDの発症には、リコモジュリンが制御しうる未だ明らかとなっていない炎症機序が関与していると考えられた。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20K17373, 研究期間(年度):2020-04-01 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「慢性GVHD発症機序の探索: リコモジュリンの慢性GVHD予防機序解明を通して」課題番号20K17373\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K17373/20K17373seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058873","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=40823555"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=40823555","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K17373/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K17373/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K17373/20K17373seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20K17373/20K17373seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-16"}],"displaytype":"detail","filename":"HO-PR-FUJIKI-T-kaken 2022-4p.pdf","filesize":[{"value":"276.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-FUJIKI-T-kaken 2022-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52579/files/HO-PR-FUJIKI-T-kaken 2022-4p.pdf"},"version_id":"eb78c21a-000e-4ee7-a913-048651613f85"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性GVHD発症機序の探索: リコモジュリンの慢性GVHD予防機序解明を通して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性GVHD発症機序の探索: リコモジュリンの慢性GVHD予防機序解明を通して"},{"subitem_title":"The preventive mechanism of recombinant thrombomodulin for sclerodermatous chronic GVHD in the rodent model.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-16"},"publish_date":"2023-02-16","publish_status":"0","recid":"52579","relation_version_is_last":true,"title":["慢性GVHD発症機序の探索: リコモジュリンの慢性GVHD予防機序解明を通して"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:30:26.983083+00:00"}