{"created":"2023-07-27T06:56:02.092117+00:00","id":52591,"links":{},"metadata":{"_buckets":{"deposit":"026b3a3b-51fa-49f6-a6bc-af6f98ecff46"},"_deposit":{"created_by":18,"id":"52591","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52591"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052591","sets":["2812:2813:3929"]},"author_link":["93712"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"14p.","bibliographicVolumeNumber":"2017-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wong, W. R."}],"nameIdentifiers":[{"nameIdentifier":"93712","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30464035","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30464035"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞核は、核膜と呼ばれる二重膜に覆われている。タンパク質やmRNAといった核内外の物質の能動的なやりとりには、核膜にある唯一のゲートである核膜孔が使用されている。核膜孔は核膜孔複合体（Nuclear Pore Complex: NPC）から成り立っており、その複合体は約30種類のNPCタンパク質（ヌクレオポリン）により構成されている。\n本研究課題では、大腸がん進行におけるNPCクロマチンの関係性の病理学的メカニズムを探求することを目的とし、ヌクレオポリンとクロマチン相互作用による大腸がんの病態解明を試み、実施期間中、ヌクレオポリンのがん病態における役割について明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"The cell nucleus is covered with a double membrane called the nuclear envelope. Nuclear pores, which are the only gates in the nuclear envelope, are used for active transfer of substances inside and outside the nucleus such as proteins and mRNA. The nuclear pore is composed of a nuclear pore complex (Nuclear Pore Complex: NPC), and the complex is composed of about 30 different NPC proteins (nucleoporins). In this research project, we aimed to explore the pathological mechanism of the relationship of NPC and chromatin in the progression of colorectal cancer. During the implementation period, we clarified the role of nucleoporins in cancer pathology.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K08655, 研究期間(年度):2017-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「核膜孔タンパク質とクロマチン相互作用による大腸がんの病態解明」研究成果報告書　課題番号17K08655\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K08655/17K08655seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学ナノ生命科学研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058885","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=30464035"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=30464035","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K08655/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K08655/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K08655/17K08655seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K08655/17K08655seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wong, Wung Chuen Richard"}],"nameIdentifiers":[{"nameIdentifier":"93712","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30464035","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30464035"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"FR-PR-WONG-WR-kaken 2020-14p.pdf","filesize":[{"value":"203.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-WONG-WR-kaken 2020-14p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52591/files/FR-PR-WONG-WR-kaken 2020-14p.pdf"},"version_id":"752a712c-60e3-4cc0-ac6a-55fb927730bc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"核膜孔タンパク質とクロマチン相互作用による大腸がんの病態解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"核膜孔タンパク質とクロマチン相互作用による大腸がんの病態解明"},{"subitem_title":"Elucidation of colorectal cancer pathology by interaction between nuclear pore protein and chromatin","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"52591","relation_version_is_last":true,"title":["核膜孔タンパク質とクロマチン相互作用による大腸がんの病態解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:25:20.457895+00:00"}