{"created":"2023-07-27T06:56:03.938914+00:00","id":52636,"links":{},"metadata":{"_buckets":{"deposit":"89348250-e370-4d93-b905-4afb0524dbc3"},"_deposit":{"created_by":18,"id":"52636","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52636"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052636","sets":["2812:2813:4014"]},"author_link":["84171","84167"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2019-08-30 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトの認知機能を改善させるergothioneine (ERGO)を経口投与したマウス及び対照群の記憶を司る海馬歯状回(DG)においてプロテオミクス解析を行い、発現が増加したある候補蛋白質に着目し、その発現を抑制するアデノ随伴ウイルス(AAV)を構築し、マウスDG特異的にこのAAVを感染させると神経突起の伸長が抑制された。\n健常人と軽度認知障害患者をERGO投与群と偽薬投与群に分け、血清中エクソソーム画分を比較すると、ある候補蛋白質の発現量がERGO投与群で有意に高く、その発現量と血清中ERGO濃度および一部の認知機能検査の評価項目と正の相関を示した。","subitem_description_type":"Abstract"},{"subitem_description":"Ergothioneine (ERGO) is known to enhance cognitive function in human. Proteome analysis in mice showed oral administration of ERGO remarkably increased several proteins in hippocampal dentate gyrus (DG). Knockdown of a candidate protein in murine hippocampal DG by adeno-associated virus significantly enhanced neurite outgrowth, which may be one of the mechanisms underlying cognitive enhancement by ERGO.\nProtein expression profile on exosomes derived from the brain in plasma may reflect the ERGO-induced enhancement of cognitive function. Expression of a candidate protein on exosomes in serum was associated with ERGO exposure and cognitive function, which might be a possible biomarker for assessment of ERGO-induced beneficial activity in the human brain.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K23797, 研究期間(年度):2019-08-30 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「記憶学習のメカニズム解析及び血漿中脳由来エクソソームを利用した記憶学習能力の評価」研究成果報告書　課題番号19K23797\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K23797/19K23797seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058930","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00843062"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00843062","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K23797/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K23797/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K23797/19K23797seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K23797/19K23797seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-25"}],"displaytype":"detail","filename":"PH-PR-ISHIMOTO-T-kaken 2021-8p.pdf","filesize":[{"value":"161.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIMOTO-T-kaken 2021-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52636/files/PH-PR-ISHIMOTO-T-kaken 2021-8p.pdf"},"version_id":"bb7fd26f-57de-4a30-9ef7-539960bab86b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"記憶学習のメカニズム解析及び血漿中脳由来エクソソームを利用した記憶学習能力の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"記憶学習のメカニズム解析及び血漿中脳由来エクソソームを利用した記憶学習能力の評価"},{"subitem_title":"Analysis on novel mechanism(s) of learning and memory and evaluation of cognitive function using brain-derived exosomes in plasma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-25"},"publish_date":"2022-02-25","publish_status":"0","recid":"52636","relation_version_is_last":true,"title":["記憶学習のメカニズム解析及び血漿中脳由来エクソソームを利用した記憶学習能力の評価"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:45:43.703974+00:00"}