{"created":"2023-07-27T06:56:04.787562+00:00","id":52675,"links":{},"metadata":{"_buckets":{"deposit":"b9a76493-f715-4dc8-a88c-009ec379f8f7"},"_deposit":{"created_by":18,"id":"52675","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52675"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052675","sets":["2812:2813:4014"]},"author_link":["30642"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2019-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakade, Kyohei"}],"nameIdentifiers":[{"nameIdentifier":"30642","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20838924","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20838924"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、細胞内の概日リズムの異常が癌の発生および進展に関与する可能性が示唆されているが、癌の自然発症モデルを用いてこの関係を直接証明した報告はない。本研究グループはこれまで子宮特異的にPten遺伝子を欠損させた子宮体癌の自然発症マウスモデルを作成・解析してきたが、最近時計遺伝子と生殖・周産期疾患との関係を調べる目的で子宮特異的に時計遺伝子Bmal1を欠損させたマウスの作出に成功した。そこで本研究ではPten欠損子宮体癌マウスを基調に してBmal1を追加欠損させたマウスを 作出し、子宮体癌の発生と筋層浸潤やリンパ節転移などに対する時計遺伝子の関与について検討した。","subitem_description_type":"Abstract"},{"subitem_description":"Recently, it has been suggested that abnormalities in intracellular circadian rhythm may be involved in the development and progression of cancer, but there are no reports that directly prove this relationship using a spontaneous model of cancer.\nThis research group has created and analyzed a spontaneous mouse model of endometrial cancer in which the Pten gene is deleted in a uterine-specific manner. We also succeeded in producing a mouse in which the clock gene Bmal1 was deficient specifically in the uterus for the purpose of investigating the relationship between the clock gene and reproductive / perinatal diseases.\nIn this project, we created mice with additional Bmal1 deficiency based on Pten-deficient endometrial cancer mice, and investigated the involvement of clock genes in the development and progression of endometrial cancer and lymph node metastasis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K18634, 研究期間(年度):2019-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「子宮体癌自然発症マウスを用いた時計遺伝子異常による癌発生と進展誘導機構の解析」研究成果報告書　課題番号19K18634\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K18634/19K18634seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058969","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20838924"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20838924","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K18634/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K18634/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K18634/19K18634seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K18634/19K18634seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中出, 恭平"}],"nameIdentifiers":[{"nameIdentifier":"30642","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20838924","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20838924"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-25"}],"displaytype":"detail","filename":"ME-PR-NAKADE-K-kaken 2021-4p.pdf","filesize":[{"value":"147.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKADE-K-kaken 2021-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52675/files/ME-PR-NAKADE-K-kaken 2021-4p.pdf"},"version_id":"b32ec4cb-16fe-4378-bf4a-01bc838b54a2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"子宮体癌自然発症マウスを用いた時計遺伝子異常による癌発生と進展誘導機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮体癌自然発症マウスを用いた時計遺伝子異常による癌発生と進展誘導機構の解析"},{"subitem_title":"Analysis of cancer development and progression mechanism due to clock gene abnormality using spontaneously developing mice for endometrial cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-25"},"publish_date":"2022-02-25","publish_status":"0","recid":"52675","relation_version_is_last":true,"title":["子宮体癌自然発症マウスを用いた時計遺伝子異常による癌発生と進展誘導機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:19:30.866690+00:00"}