{"created":"2023-07-27T06:56:05.102994+00:00","id":52684,"links":{},"metadata":{"_buckets":{"deposit":"e6646009-dc9d-4fd2-bed7-bbcf88133608"},"_deposit":{"created_by":18,"id":"52684","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52684"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052684","sets":["2812:2813:2815"]},"author_link":["94353"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2017-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"現在、標準的な治療をおこなっても完治できない神経膠腫の新規治療の開発を目指して研究を実施した。腫瘍の周囲の微小環境を整備する機構と深く関連するマイクログリアについて注目し、また細胞間の情報伝達を担うとされるエクソソームという膜小胞を介したメカニズムに着眼した。エクソソームの産生を抑えた細胞を作製したところ、腫瘍の形成が弱まることがわかった。また、腫瘍から分泌されたエクソソームをマイクログリアに加えると、細胞内部で様々な重要な分子の発現が変化することを解明した。","subitem_description_type":"Abstract"},{"subitem_description":"Glioma is the most common primary brain tumor. Exosomes are one of the extracellular vesicles and they can transfer many molecules from cells to cells. We studied a relationship between glioma and exosomes to develop a new treatment for glioma. We established glioma cells that cannot produce enough exosomes and showed that these cells can only make small tumors. And, we identified that exosomes from glioma cells can activate microglia.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K16635, 研究期間(年度):2017-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「神経膠腫におけるエクソソーム解析とNegr1による新規治療の開発」課題番号17K16635\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K16635/17K16635seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058978","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00722042"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00722042","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K16635/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-17K16635/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K16635/17K16635seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-17K16635/17K16635seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-24"}],"displaytype":"detail","filename":"HO-PR-TSUTSUI-T-kaken 2019-4p.pdf","filesize":[{"value":"191.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TSUTSUI-T-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52684/files/HO-PR-TSUTSUI-T-kaken 2019-4p.pdf"},"version_id":"1a31a31f-1b63-4f3f-b305-6fd1883a7d94"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経膠腫におけるエクソソーム解析とNegr1による新規治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経膠腫におけるエクソソーム解析とNegr1による新規治療の開発"},{"subitem_title":"An analysis of glioma-derived exosomes and development of a new treatment for glioma with exosomes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-24"},"publish_date":"2020-09-24","publish_status":"0","recid":"52684","relation_version_is_last":true,"title":["神経膠腫におけるエクソソーム解析とNegr1による新規治療の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:30:15.011579+00:00"}