{"created":"2023-07-27T06:56:05.281808+00:00","id":52689,"links":{},"metadata":{"_buckets":{"deposit":"0472d00d-60aa-4ab6-9602-398e617af8ba"},"_deposit":{"created_by":18,"id":"52689","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52689"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052689","sets":["2812:2813:4085"]},"author_link":["77731","24743"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2019-04-01 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Retinoic acid-inducible gene I (RIG-I) is a key molecule that recognizes the virus RNA in the cytoplasm and initiates an immune response. Hepatitis B virus (HBV) and hepatitis C virus (HCV) skillfully evade the immune response by RIG-I to establish a persistent infection, but the entire escape mechanism has not been elucidated.\nIn this study, we identified Selenoprotein P (SeP) mRNA as a host factor that controls virus recognition by RIG-I, and clarified the mechanism of immune escape during virus infection.","subitem_description_type":"Abstract"},{"subitem_description":"Retinoic acid-inducible gene I (RIG-I) は、細胞内に侵入したウイルスを認識して免疫応答をスタートさせる司令塔分子である。B型肝炎ウイルス (HBV) や C型肝炎ウイルス (HCV)は、RIG-Iによる免疫応答を巧みに回避して持続感染を成立させるが、その逃避機構の全容は解明されていない。\n本研究では、RIG-Iによるウイルス認識を制御する宿主因子としてSelenoprotein P (SeP) mRNAを同定し、ウイルス感染時の免疫逃避機構を明らかにした。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K17427, 研究期間(年度):2019-04-01 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「RIP-Seq法を用いたRIG-IのRNA decoy探索と核酸医薬への応用」課題番号19K17427\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K17427/19K17427seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058983","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=10828099"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=10828099","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K17427/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K17427/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K17427/19K17427seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K17427/19K17427seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-16"}],"displaytype":"detail","filename":"ME-PR-MURAI-K-kaken 2022-5p.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MURAI-K-kaken 2022-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52689/files/ME-PR-MURAI-K-kaken 2022-5p.pdf"},"version_id":"d6f14438-316b-4fc8-98a5-91e5dbee98dc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"RIP-Seq法を用いたRIG-IのRNA decoy探索と核酸医薬への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RIP-Seq法を用いたRIG-IのRNA decoy探索と核酸医薬への応用"},{"subitem_title":"Identification of a host RNA decoy to RIG-I using RIP-Seq method and application to oligonucleotide therapeutics","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-16"},"publish_date":"2023-02-16","publish_status":"0","recid":"52689","relation_version_is_last":true,"title":["RIP-Seq法を用いたRIG-IのRNA decoy探索と核酸医薬への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:30:12.450085+00:00"}