{"created":"2023-07-27T06:56:05.325987+00:00","id":52693,"links":{},"metadata":{"_buckets":{"deposit":"678fe47d-46cb-45bd-9be8-fd116d61aab7"},"_deposit":{"created_by":18,"id":"52693","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52693"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052693","sets":["2812:2813:4085"]},"author_link":["94343"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2019-08-30 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyagawa, Taro"}],"nameIdentifiers":[{"nameIdentifier":"94343","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20738207","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20738207"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Acute kidney injury (AKI) is an important risk factor for the development of chronic kidney disease and end-stage renal failure. This study focused on soluble RAGE (sRAGE) and investigated the protective mechanism of sRAGE against AKI. In an ischemia-reperfusion model of AKI, RAGE deficiency exacerbated AKI.\nIn proximal tubular cells exposed to hypoxia, inflammatory cytokines including high mobility group box 1 (HMGB1) were decreased and cell proliferative capacity was improved in the presence of sRAGE.\nIn an AKI model, sRAGE treatment reduced AKI. These results suggest that sRAGE may be protective in ischemia-reperfusion-induced AKI.","subitem_description_type":"Abstract"},{"subitem_description":"急性腎障害（AKI）は慢性腎臓病や末期腎不全を発症させる重要な危険因子である。本研究は、可溶型RAGE（sRAGE）に着目し、AKIに対するsRAGEの保護機構について検討した。虚血再灌流によるAKIモデルにおいて、RAGE欠損によりAKIが増悪した。低酸素曝露を施した近位尿細管細胞において、sRAGE存在下でHigh mobility group box1 (HMGB1)をはじめとした炎症性サイトカインが低下し、細胞増殖能が改善した。AKIモデルにおいて、sRAGE投与によりAKIが軽減した。以上の結果から、虚血再灌流によるAKIにおいて、sRAGEが保護的に作用する可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K23941, 研究期間(年度):2019-08-30 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「尿細管障害におけるRAGE分子種の機能的役割」課題番号19K23941\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K23941/19K23941seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00058987","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20738207"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20738207","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K23941/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K23941/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K23941/19K23941seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K23941/19K23941seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮川, 太郎"}],"nameIdentifiers":[{"nameIdentifier":"94343","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20738207","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20738207"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-24"}],"displaytype":"detail","filename":"HO-PR-MIYAGAWA-T-kaken 2022-7p.pdf","filesize":[{"value":"247.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MIYAGAWA-T-kaken 2022-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52693/files/HO-PR-MIYAGAWA-T-kaken 2022-7p.pdf"},"version_id":"27d195a4-4d53-4d04-94fa-fc17f8b87612"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"尿細管障害におけるRAGE分子種の機能的役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"尿細管障害におけるRAGE分子種の機能的役割"},{"subitem_title":"急性腎障害 / RAGE / sRAGE / HMGB1","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-24"},"publish_date":"2023-02-24","publish_status":"0","recid":"52693","relation_version_is_last":true,"title":["尿細管障害におけるRAGE分子種の機能的役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:15:47.621828+00:00"}