{"created":"2023-07-27T06:56:06.486655+00:00","id":52751,"links":{},"metadata":{"_buckets":{"deposit":"afbdbdcc-578d-4223-9654-5ddff38463de"},"_deposit":{"created_by":18,"id":"52751","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52751"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052751","sets":["2812:2813:3929"]},"author_link":["94076","94077"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2017-04-01 – 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IgG4-AAAの外膜におけるMMPs発現は，動脈瘤の形成と進行のみならず，線維性外膜のリモデリングとの関連が示唆された．血管内治療後のIgG4-AAA の中で，術後IgG4上昇を示す群は，術前IL-6高値，術後瘤径拡大を示し，進行傾向のある高リスク群であった．この群は，術前IgG4／IgG比，血清MMP-9，単球，好酸球の比率がいずれも高く，これらはIgG4-AAAの術前予後予測因子の候補である．","subitem_description_type":"Abstract"},{"subitem_description":"MMP-9 production in various immune-cells of the adventitia was characteristic of IgG4-AAA and was highly associated with the activity of IgG4-AAA. MMPs expression in the adventitia of IgG4-AAA may be involved in lymphoid follicle formation and not only in the formation and progression of aneurysms, but also in the remodeling of the thick fibrous adventitia.\nAfter intravascular treatment, among the IgG4-AAA, the IgG4-AAA-up group (serum IgG4 increasing after treatment) showed a preoperative high IL-6 and an increase of postoperative aneurysm diameter. Thus, the IgG4-AAA-up group was thought to be as a high-risk group with a progressive tendency. The IgG4-AAA-up group is characterized by high preoperative IgG4 / IgG ratio, high MMP-9, and high monocyte to eosinophil ratio. These indicators are candiate of prognostic factors for IgG4-AAA.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K10773, 研究期間(年度):2017-04-01 – 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「IgG4関連血管病変の進展・予後因子の解明」研究成果報告書　課題番号17K10773\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10773/17K10773seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059044","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20444200"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20444200","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10773/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10773/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10773/17K10773seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10773/17K10773seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"ME-PR-KASASHIMA-S-kaken 2020-7p.pdf","filesize":[{"value":"383.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":" 1.ME-PR-KASASHIMA-S-kaken 2020-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52751/files/ME-PR-KASASHIMA-S-kaken 2020-7p.pdf"},"version_id":"b549b1b8-ff7b-4997-8fbd-bfc845eee9a8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"IgG4関連血管病変の進展・予後因子の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IgG4関連血管病変の進展・予後因子の解明"},{"subitem_title":"Prognostic factors of IgG4-related vascular disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"52751","relation_version_is_last":true,"title":["IgG4関連血管病変の進展・予後因子の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:09:36.627935+00:00"}