{"created":"2023-07-27T06:56:06.531392+00:00","id":52752,"links":{},"metadata":{"_buckets":{"deposit":"0f5e1053-4bba-465b-810b-ff178b74958d"},"_deposit":{"created_by":18,"id":"52752","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52752"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052752","sets":["2812:2813:2817"]},"author_link":["94076","94077"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、サイトカイン(CKs)バランスに注目し、IgG4関連血管病変の病因病態の解明を目的とし、IgG4関連大動脈瘤(IgG4-AAA)、IgG4非関連炎症性大動脈瘤、通常の動脈硬化性大動脈瘤、解剖例の正常動脈を対象とし、術前血清CKs、組織のCKs発現細胞を免疫染色及びIn situ hybridizationにて同定した。IgG4-AAAのCKs発現には２つの側面がある事が解明された。１つはIL-10, IL-13優位なTh２優位あるいはTreg優位な環境であり他臓器のIgG4関連疾患と同様のサCKsである。もう１つは、特徴的なIL-6産生であり、IgG4-AAAの血管炎の側面を示す。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we identify a cytokine profile in the blood and local tissue of the patients with IgG4-AA, IgG4-AA), non-IgG4-related inflammatory abdominal aortic aneurysm, atherosclerotic AAA, almost normal aorta without dilatation were examined by (1) serum levels interleukin (IL)-4, IL-10, IL-13, and interferon (IFN)-g; (2) using resected the aortic tissues, immunohistochemical and mRNA-in situ hybrydization (ISH), local expression of the cytokines described above, CD34 , and CD163. Serum IL-10 in IgG4-AA were significantly higher than in atherosclerotic arteriopathies. IL-13 levels were elevated in 2 patients, all with IgG4-AA. Immunohistochemical analysis revealed that the number of immunopositive cells for IL-4, IL-10 and IL-13 were increased significantly in the adventitia of IgG4-AA than in aAAA and autopsy controls. ISH confirmed IL-10 and IL-13 mRNA expression in the adventitia of IgG4-AA. Co-expression of IL-13-mRNA and CD34-mRNA or CD168-mRNA was detected in IgG4-AA.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26462119, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「サイトカインバランスからみたIgG4関連血管病変の病態解析」研究成果報告書　課題番号26462119\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462119/26462119seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059045","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系 / 金沢医療センター臨床研究部"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20444200"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20444200","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462119/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462119/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462119/26462119seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462119/26462119seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-10"}],"displaytype":"detail","filename":"ME-PR-KASASHIMA-S-kaken 2017-4p.pdf","filesize":[{"value":"166.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KASASHIMA-S-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52752/files/ME-PR-KASASHIMA-S-kaken 2017-4p.pdf"},"version_id":"5603d05c-b457-4fa8-a611-426209b9e04d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"サイトカインバランスからみたIgG4関連血管病変の病態解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サイトカインバランスからみたIgG4関連血管病変の病態解析"},{"subitem_title":"Cytokine valance in Patients with Immunoglobulin G4-Related Aortic Aneurysm","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-10"},"publish_date":"2020-09-10","publish_status":"0","recid":"52752","relation_version_is_last":true,"title":["サイトカインバランスからみたIgG4関連血管病変の病態解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:20:09.319049+00:00"}