{"created":"2023-07-27T06:56:06.620239+00:00","id":52754,"links":{},"metadata":{"_buckets":{"deposit":"4a5f36b2-cabd-42cd-8119-fcbf075c95fb"},"_deposit":{"created_by":18,"id":"52754","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52754"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052754","sets":["2812:2813:2815"]},"author_link":["94099","94100"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 – 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"GABA神経伝達の障害は，自閉症スペクトラム障害（ASD）における神経ネットワーク障害仮説の神経基盤として重要な役割を担う．周産期にオキシトシンはGABA神経を興奮性から抑制性にシフトし，その欠如がASDの発症に関連するとされ，近年オキシトシンはASDの治療薬として注目されている．一方，γ帯域律動はGABA神経活動を，また複雑ネットワーク理論は神経ネットワーク活動を探る手段として注目されている．\n本研究では，新規複雑ネットワーク解析を開発し、それらを駆使した脳磁図解析によってASDにおけるGABA神経活動および神経ネットワークの障害を浮き彫りにし，さらにオキシトシンの治療効果を踏まえて検討した．","subitem_description_type":"Abstract"},{"subitem_description":"GABAergic dysfunction plays a crucial role in the pathogenesis of aberrant neural network hypothesis in autism spectrum disorder (ASD). The perinatal excitatory-to-inhibitory shift of GABA is mediated by oxytocin. The deficit of this oxytocin-mediated GABA inhibition reportedly associates with the prevalence of ASD. Therefore, oxytocin has been receiving great attention as a neuroprotective agent of ASD.\nGamma-band oscillatory activity is reportedly involved in mediating GABAergic activity. Additionally, complex network theory is a useful approach in understanding brain network. This research aimed to elucidate therapeutic mechanisms of oxytocin in ASD using MEG with newly developed analysis methods.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K10206, 研究期間(年度):2016-04-01 – 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「神経ネットワーク障害仮説に着目した自閉性障害におけるオキシトシン作用機序の解明」課題番号16K10206\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10206/16K10206seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059047","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学子どものこころの発達研究センター / 福井大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00377459"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00377459","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10206/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10206/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10206/16K10206seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10206/16K10206seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-24"}],"displaytype":"detail","filename":"CH-PR-TAKAHASHI-T-kaken 2019-4p.pdf","filesize":[{"value":"830.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-TAKAHASHI-T-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52754/files/CH-PR-TAKAHASHI-T-kaken 2019-4p.pdf"},"version_id":"1ae45452-cda6-42d2-ac9c-fd848af5c13b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経ネットワーク障害仮説に着目した自閉性障害におけるオキシトシン作用機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経ネットワーク障害仮説に着目した自閉性障害におけるオキシトシン作用機序の解明"},{"subitem_title":"Neural correlates of the oxytocin in the treatment of autism spectrum disorder based on aberrant neural network hypothesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-24"},"publish_date":"2020-09-24","publish_status":"0","recid":"52754","relation_version_is_last":true,"title":["神経ネットワーク障害仮説に着目した自閉性障害におけるオキシトシン作用機序の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:30:10.758452+00:00"}