{"created":"2023-07-27T06:56:09.040064+00:00","id":52821,"links":{},"metadata":{"_buckets":{"deposit":"266e6e1a-3a96-4337-9eb0-42863f395e99"},"_deposit":{"created_by":18,"id":"52821","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52821"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052821","sets":["2812:2813:2816"]},"author_link":["94753"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"金沢大学薬学部にて開発された１Pt（カチオン型シスプラチン）と３Pt（アニオン型シスプラチン）という２つの新規薬剤の頭頸部癌細胞株に対する効果を従来のシスプラチンと比較した。in vitroでは１Pt、３Pt共にシスプラチンと比較してIC50は高く、シスプラチンより抗腫瘍効果は低かった。対してin vivoではシスプラチンと比較して同等からやや良い結果となった。腎障害の程度はシスプラチンと比較して低かった。体内動態では３Ptはシスプラチンと比較して24hr時点での骨へ３倍以上の集積を示した。また骨浸潤モデルでは骨浸潤癌に対して浸潤を抑制する結果を示した。","subitem_description_type":"Abstract"},{"subitem_description":"The effect of two novel drugs, 1 Pt (cationic cisplatin) and 3 Pt (anionic cisplatin) developed in Kanazawa University School of Pharmacy, on head and neck cancer cell lines was compared with conventional cisplatin. IC50 was higher in cisplatin than in cisplatin in both 1Pt and 3Pt in vitro, and the antitumor effect was lower than that of cisplatin. In comparison with cisplatin in vivo, the results were slightly better than those of cisplatin. The degree of kidney damage was lower than that of cisplatin. In the body kinetics 3Pt showed more than 3 times more accumulation in bone at 24 hr compared to cisplatin. In addition, in the bone invasion model, it showed a suppression of invasion against bone invasive cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K20234, 研究期間(年度):2016-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「電荷型白金抗癌剤による頭頸部癌新規治療戦略の基礎研究」課題番号16K20234\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20234/16K20234seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059114","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00707573"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00707573","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K20234/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K20234/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20234/16K20234seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20234/16K20234seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-12"}],"displaytype":"detail","filename":"HO-PR-KASAHARA-Y-kaken 2018-4p.pdf","filesize":[{"value":"367.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KASAHARA-Y-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52821/files/HO-PR-KASAHARA-Y-kaken 2018-4p.pdf"},"version_id":"1d7439cd-99c5-4d2b-9202-3f4d3fe70caa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"電荷型白金抗癌剤による頭頸部癌新規治療戦略の基礎研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"電荷型白金抗癌剤による頭頸部癌新規治療戦略の基礎研究"},{"subitem_title":"Fundamental research on novel therapeutic strategies for head and neck cancer using charged platinum anticancer drug","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-12"},"publish_date":"2020-10-12","publish_status":"0","recid":"52821","relation_version_is_last":true,"title":["電荷型白金抗癌剤による頭頸部癌新規治療戦略の基礎研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:53:53.725317+00:00"}