{"created":"2023-07-27T06:56:09.130091+00:00","id":52823,"links":{},"metadata":{"_buckets":{"deposit":"9c37bf64-3696-48cb-9073-edd1744cd6e8"},"_deposit":{"created_by":18,"id":"52823","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52823"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052823","sets":["2812:2813:2817"]},"author_link":["94756","48011"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞のがん化とゲノムDNAのメチル化との関連については膨大な研究の蓄積があるのに対し、がん化とDNAの脱メチル化制御についての研究は未だ十分ではない。申請者はがん培養細胞株において、DNAの能動的な脱メチル化機構の一員であるTET1(Ten-eleven translocation 1)遺伝子の発現レベルの上昇と低下がそれぞれ異なる局面において起こることを見出したことから、同遺伝子の転写制御機序と悪性腫瘍における機能の解析を行うこととした。これにより、TET1遺伝子の転写抑制が起きる培養環境や、同遺伝子の標的遺伝子候補の同定がなされた","subitem_description_type":"Abstract"},{"subitem_description":"On the other hand there have been many reports of the relationship between the molecular machinery of DNA methylation and malignant tumor, the relationship of DNA demethylation mechanism and cancer remains unclear. Upon starting the research, we have found that the transcriptional level of TET1 (Ten-eleven translocation 1) gene, a member of active DNA demethylation pathway, is not only upregulated in some cell lines but also downregulated in other cancer cell lines. We found the cellular environment inducing transcriptional repression or upregulation of TET1 gene and the candidate of TET1 target genes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26870222, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「DNA脱メチル化関連酵素TET1のがん細胞における機能解析」研究成果報告書　課題番号26870222\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26870222/26870222seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059116","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=40571211"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=40571211","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26870222/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26870222/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26870222/26870222seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26870222/26870222seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-12"}],"displaytype":"detail","filename":"ME-PR-TANGE-S-kaken 2017-4p.pdf","filesize":[{"value":"582.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TANGE-S-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52823/files/ME-PR-TANGE-S-kaken 2017-4p.pdf"},"version_id":"f4804397-4cca-4819-a571-37454833a4ca"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DNA脱メチル化関連酵素TET1のがん細胞における機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNA脱メチル化関連酵素TET1のがん細胞における機能解析"},{"subitem_title":"An investigation for involvement of TET1 gene in tumorigenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-12"},"publish_date":"2020-10-12","publish_status":"0","recid":"52823","relation_version_is_last":true,"title":["DNA脱メチル化関連酵素TET1のがん細胞における機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:20:17.922508+00:00"}