{"created":"2023-07-27T06:56:09.443132+00:00","id":52833,"links":{},"metadata":{"_buckets":{"deposit":"67c93af1-d3b0-4401-b1f1-19196b919b86"},"_deposit":{"created_by":18,"id":"52833","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52833"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052833","sets":["2812:2813:4085"]},"author_link":["94582","94583"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"\t2019-04-01 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mikhailov, Alexander"}],"nameIdentifiers":[{"nameIdentifier":"94583","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00817364","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00817364"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The execution of this project was affected by COVID-19 pandemic. The PI, based in Berlin and working part-time in Kanazawa, could not freely travel to Japan. Nonetheless, the research was to a large extent performed as planned. Hydrodynamic effects of active internal motions in mechano-chemical enzymes were explored. Analysis of simplified dimer models led to accurate estimates for diffusion enhancement in solutions of catalytically active enzymes. The phenomenon of molecular dancing, based on exchange of momenta between enzymes and surrounding fluid, was proposed, and its theory was developed. This has allowed us to explain the effects of boosted diffusion for single molecules of enzymes. Moreover, glass-like properties of dense solutions of catalytically active enzymes were numerically explored. It has been demonstrated that conformational activity of enzymes can have a strong effect on such colloidal glasses, leading to an effective fluidization of them.","subitem_description_type":"Abstract"},{"subitem_description":"本研究計画の遂行はCOVID-19の感染拡大に影響された。研究代表者はベルリンと金沢を拠点としており、自由に渡航できなくなった。しかし研究はほぼ予定通り進行し、酵素の活発な内部運動による流体力学的効果を解明した。まず、簡略化したダンベルモデルの解析により、触媒活性を持つ酵素の溶液における拡散の促進を正確に推定できた。また、酵素と周囲流体の運動量交換に基づく分子ダンス現象を提案し、その理論を構築した。これにより、酵素1分子に対する拡散増強効果を説明した。さらに、触媒活性を持つ酵素の濃厚溶液のガラス的性質を数値的に調べ、変形を伴う酵素活性がコロイドガラスの効果的な流動化をもたらすことを実証した。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K03765, 研究期間(年度):2019-04-01 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「Enzymes as Active Matter at Nanoscales」課題番号19K03765\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K03765/19K03765seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学ナノ生命科学研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059126","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00817364"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00817364","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K03765/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19K03765/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K03765/19K03765seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K03765/19K03765seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mikhailov, Alexander S."}],"nameIdentifiers":[{"nameIdentifier":"94582","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00817364","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00817364"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-17"}],"displaytype":"detail","filename":"NAL-PR-MIKHAILOV-A-kaken 2022-9p.pdf","filesize":[{"value":"327.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"NAL-PR-MIKHAILOV-A-kaken 2022-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52833/files/NAL-PR-MIKHAILOV-A-kaken 2022-9p.pdf"},"version_id":"4d186174-ffe0-4b17-988d-6d246850906a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Enzymes as Active Matter at Nanoscales","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enzymes as Active Matter at Nanoscales"},{"subitem_title":"Enzymes as Active Matter at Nanoscales","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-17"},"publish_date":"2023-02-17","publish_status":"0","recid":"52833","relation_version_is_last":true,"title":["Enzymes as Active Matter at Nanoscales"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:15:45.808721+00:00"}