{"created":"2023-07-27T06:56:10.072941+00:00","id":52849,"links":{},"metadata":{"_buckets":{"deposit":"ceb2661c-aa60-4b0a-830d-7374724b8902"},"_deposit":{"created_by":18,"id":"52849","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52849"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052849","sets":["2812:2813:2817"]},"author_link":["94759"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okada, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"94759","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60742377","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60742377"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"乳癌は、遺伝子発現プロファイルにより5つのサブタイプに分類される。腫瘍増殖および悪性化を促進するために異なるサブタイプ間での協同作用が重要であるという「癌の不均一性モデル」が提唱されており、乳癌治療を困難にしている原因の一つであると考えられている。我々は、NFYAがEMT進行に伴い、スプライシングバリアントの発現パターンを変えることで、段階的に2つの機能を果たし、癌の不均一性の形成を促進していることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Breast cancer is classified into five subtypes by gene expression profile. In case of breast cancers, cancer heterogeneity that some different subtypes cooperate to enhance malignant progression is proposed. It is suggested that cancer heterogeneity makes it difficult to develop cancer therapy. We elucidated that NFYA plays two different roles by switching the expression of splicing variants, thereby NFYA induces the switching of breast cancer subtypes and enhances the acquisition of cancer heterogeneity.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K18407, 研究期間(年度):2015-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「Cancer heterogeneity獲得・維持機構におけるNFYAの機能解明」研究成果報告書　課題番号15K18407\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18407/15K18407seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所 / 京都大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059142","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60742377"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60742377","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18407/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18407/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18407/15K18407seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18407/15K18407seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 宣宏"}],"nameIdentifiers":[{"nameIdentifier":"94759","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60742377","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60742377"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-12"}],"displaytype":"detail","filename":"CA-PR-OKADA-N-kaken 2017-4p.pdf","filesize":[{"value":"439.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-OKADA-N-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52849/files/CA-PR-OKADA-N-kaken 2017-4p.pdf"},"version_id":"ae034bcc-23f7-420f-a9a6-8f945ded59ce"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Cancer heterogeneity獲得・維持機構におけるNFYAの機能解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cancer heterogeneity獲得・維持機構におけるNFYAの機能解明"},{"subitem_title":"Analysis of the function of NFYA in cancer heterogeneity formation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-12"},"publish_date":"2020-10-12","publish_status":"0","recid":"52849","relation_version_is_last":true,"title":["Cancer heterogeneity獲得・維持機構におけるNFYAの機能解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:40:26.378897+00:00"}