{"created":"2023-07-27T06:56:10.210337+00:00","id":52852,"links":{},"metadata":{"_buckets":{"deposit":"fcda1ab6-81ba-4518-9cb1-d761562f1383"},"_deposit":{"created_by":18,"id":"52852","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52852"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052852","sets":["2812:2813:2817"]},"author_link":["30685","45324"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は悪性脳腫瘍のひとつである膠芽腫の早期発見を可能とし、病勢を反映するバイオマーカーを同定することを目的とする。患者由来の髄液を先進的なプロテオミクスによって解析し、これまでに十数種類のバイオマーカー候補タンパク質を同定した。その一部を詳細に解析したところ、腫瘍の血管新生に関わるタンパク質で、膠芽腫のバイオマオーカーとしてはこれまでに報告のない新規性の高いものであることを突き止めた。またこのタンパク質は神経膠腫の中でも悪性度の高い膠芽腫に特異的に高発現していることが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of this study is establishment of the biomarker that can identify glioblastoma, one of the most malignant brain tumor, early in the disease progression and recurrent stage. We analyzed cerebrospinal fluid derived from patients with the innovative proteomics and identified several biomarker candidate proteins. One of the candidates was involved in tumor angiogenesis and found that it is highly expressed in glioblastoma. This protein has never been reported as a biomarker of glioblastoma. In addition, it was also revealed that this candidate protein was highly expressed specifically in glioblastoma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K18427, 研究期間(年度):2015-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「革新的プロテオミクスによる髄液中の膠芽腫バイオマーカーの同定」研究成果報告書　課題番号15K18427\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18427/15K18427seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"久留米大学 / 金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059145","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=20646690"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=20646690","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18427/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18427/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18427/15K18427seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18427/15K18427seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-12"}],"displaytype":"detail","filename":"ME-PR-FURUTA-T-kaken 2017-4p.pdf","filesize":[{"value":"187.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FURUTA-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52852/files/ME-PR-FURUTA-T-kaken 2017-4p.pdf"},"version_id":"645a2cd9-9507-475f-af93-8e3e2c747e4a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"革新的プロテオミクスによる髄液中の膠芽腫バイオマーカーの同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"革新的プロテオミクスによる髄液中の膠芽腫バイオマーカーの同定"},{"subitem_title":"Identification of the biomarker in cerebrospinal fluid of glioblastoma by innovative proteomics","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-12"},"publish_date":"2020-10-12","publish_status":"0","recid":"52852","relation_version_is_last":true,"title":["革新的プロテオミクスによる髄液中の膠芽腫バイオマーカーの同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:20:23.591982+00:00"}