{"created":"2023-07-27T06:56:10.889963+00:00","id":52869,"links":{},"metadata":{"_buckets":{"deposit":"e47a5986-f49f-472e-9c72-508d988d5870"},"_deposit":{"created_by":18,"id":"52869","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52869"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052869","sets":["2812:2813:2818"]},"author_link":["95211"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Goshima, Kennichi"}],"nameIdentifiers":[{"nameIdentifier":"95211","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60706886","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60706886"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脂肪組織由来幹細胞（ADSCs）による半月板再生ついて検討した。ウサギの内側半月板に欠損を作製し、欠損部をそのままにしたコントロール群と、ADSCsの3次元培養を行い、それらを多数凝集させ欠損部に充填したADSC群で比較した。肉眼的組織連続性は、コントロール群に比しADSC群で良好な結果が得られ、組織学的にもADSC群で有意差をもってスコアが高かった(P<0.05)。また、免疫組織学的には半月板の修復部に抗Ⅰ型コラーゲンが観察され、染色性は経時的に増強する傾向を認めた。以上の結果から、ADSCsが半月板の再生を促進することが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"Purpose: To determine whether meniscal tissue could be regenerated by the implantation of adipose-derived stem cells (ADSCs) engrafted into the meniscal defect in a rabbit model of partial meniscectomy. Methods: We created full-thickness meniscal defects in the rabbit’s knee. The defects were left empty in the control group, and were filled with ADSCs which created a 3-dimensional structure of ADSCs in the ADSC group. Results: Macroscopically, full-thickness defects remained in the control group, however, the defects were not observed in any time point in the ADSC group. Histologically, there was a consistent tendency toward significantly superior tissue quality scores in the ADSC group compared with the control group at all weeks (p<.005). Regenerated tissue was positive for type I collagen and the extent of staining increased gradually over time in the ADSC group. Conclusions: This study shows that ADSCs adhere to meniscal defect and promote meniscus regeneration.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26861177, 研究期間(年度):2014-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「脂肪由来幹細胞を用いた半月板再生」課題番号26861177\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861177/26861177seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059162","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=60706886"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=60706886","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861177/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861177/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861177/26861177seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861177/26861177seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五嶋, 謙一"}],"nameIdentifiers":[{"nameIdentifier":"95211","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60706886","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60706886"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"ME-PR-GOSHIMA-K-kaken 2016-4p.pdf","filesize":[{"value":"334.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-GOSHIMA-K-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52869/files/ME-PR-GOSHIMA-K-kaken 2016-4p.pdf"},"version_id":"6e7724e6-36a8-48f7-baa5-ed2f660cb123"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪由来幹細胞を用いた半月板再生","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪由来幹細胞を用いた半月板再生"},{"subitem_title":"Scaffold-free tissue-engineered allogenic adipose-derived stem cells promote meniscus regeneration","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-05"},"publish_date":"2020-11-05","publish_status":"0","recid":"52869","relation_version_is_last":true,"title":["脂肪由来幹細胞を用いた半月板再生"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:41:27.916997+00:00"}