{"created":"2023-07-27T06:56:10.979592+00:00","id":52871,"links":{},"metadata":{"_buckets":{"deposit":"9a37843d-8a53-4f77-999f-b1495bf8be0b"},"_deposit":{"created_by":18,"id":"52871","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52871"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052871","sets":["2812:2813:2816"]},"author_link":["3002","45565"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"内因性突然変異誘導因子であるAID、APOBEC3はウイルス感染で誘導され、それらが誘導する突然変異によりウイルス発癌が起こると仮定し、上咽頭癌・中咽頭癌をウイルス感染の有無に分けて評価した。\nEBV関連上咽頭癌においてAIDが、HPV関連中咽頭癌でAPOBEC3が発現していることが分かった。in vivoで中咽頭癌へのエストロゲン刺激でAPOBEC3が誘導されることが分かり、HPV関連中咽頭癌では、エストロゲン受容体が発現し、また予後良好に関わる可能性を認めた。","subitem_description_type":"Abstract"},{"subitem_description":"We hypothesize that AID and APOBEC3, which is caused by viral infection, induce mutation in host genome and lead carcinogenesis. To clarify that, we evaluated the expression level of AID and APOBEC3 in nasopharingeal carcinom (NPC) and oropharyngeal carsinoma (OPC) depend on the presence of viral infection.\nAID expression was more frequent in EBV-positive NPC than in EBV-negative NPC. APOBEC3 expression was more frequent in HPV-positive OPC than in HPV-negative OPC. Furthermore, in vivo study showed that APOBEC3A was induced by estrogen in OPC cell line. ER expression was associated with HPV positivity in OPC. In addition, ER was a prognostic factor in HPV-positive OPC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K20236, 研究期間(年度):2016-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「AIDと上咽頭癌」課題番号16K20236\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20236/16K20236seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059164","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=00707557"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=00707557","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K20236/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K20236/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20236/16K20236seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20236/16K20236seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-12"}],"displaytype":"detail","filename":"HO-PR-KANO-M-kaken 2018-4p.pdf","filesize":[{"value":"383.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KANO-M-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52871/files/HO-PR-KANO-M-kaken 2018-4p.pdf"},"version_id":"da8f4138-42a3-4b8a-9d4e-3c9e7ee10389"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"AIDと上咽頭癌","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AIDと上咽頭癌"},{"subitem_title":"AID and nasopharyngeal carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-12"},"publish_date":"2020-10-12","publish_status":"0","recid":"52871","relation_version_is_last":true,"title":["AIDと上咽頭癌"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:54:02.972863+00:00"}