{"created":"2023-07-27T06:56:11.024895+00:00","id":52872,"links":{},"metadata":{"_buckets":{"deposit":"56759f63-7290-4bdd-a08b-831784bb4625"},"_deposit":{"created_by":18,"id":"52872","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52872"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052872","sets":["2812:2813:2816"]},"author_link":["24482","94762"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2016-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"くも膜下出血の予後を規定する因子として、脳血管攣縮などに代わり、出血後72時間以内に生じる脳浮腫や細胞障害性変化などを主体とする早期脳損傷（EBI : early brain injury）が注目されてきている。今回 EBI に対して、酸化ストレスおよび酸化ストレス反応制御転写因子である Nrf2が関与していることを明らかにするため、ラットやマウスでの血管穿通モデルを用いた動物実験を行い、両者の関連が示唆される結果を得た。今後 Nrf2をターゲットとしたくも膜下出血後の予後予測や、EBI に対する治療および治療効果判定の確立につなげていきたい。","subitem_description_type":"Abstract"},{"subitem_description":"Early brain injury (EBI) mainly focusing on cerebral edema and cytotoxicity changes occurred within 72 hours after bleeding, instead of cerebral vasospasm, has been noted as a factor that regulates the prognosis of subarachnoid hemorrhage. To clarify an oxidative stress and Nrf2, which is oxidative stress response regulatory transcription factor, is involved in EBI, we conducted animal experiments using a blood vessel penetration model in rats and mice, and we got the results that both were related. Targeting Nrf2, we would like to lead to the prognostic prediction after subarachnoid hemorrhage and the establishment of treatment and therapeutic effect judgment on EBI.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K19997, 研究期間(年度):2016-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「くも膜下出血後 EBI と転写因子 Nrf2 の関連についての検討」課題番号16K19997\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K19997/16K19997seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059165","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=50735438"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=50735438","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K19997/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K19997/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K19997/16K19997seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K19997/16K19997seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-12"}],"displaytype":"detail","filename":"ME-PR-AIDA-Y-kaken 2018-4p.pdf","filesize":[{"value":"275.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-AIDA-Y-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52872/files/ME-PR-AIDA-Y-kaken 2018-4p.pdf"},"version_id":"8e3678b0-cb0b-4a89-81fb-35cab87341b3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"くも膜下出血後 EBI と転写因子 Nrf2 の関連についての検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"くも膜下出血後 EBI と転写因子 Nrf2 の関連についての検討"},{"subitem_title":"The effect of transcription factor Nrf2 on EBI after subarachnoid hemorrhage","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-12"},"publish_date":"2020-10-12","publish_status":"0","recid":"52872","relation_version_is_last":true,"title":["くも膜下出血後 EBI と転写因子 Nrf2 の関連についての検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:54:04.430641+00:00"}