{"created":"2023-07-27T06:56:11.069543+00:00","id":52927,"links":{},"metadata":{"_buckets":{"deposit":"12150dbb-5bf6-41a5-9066-89a82ec70e14"},"_deposit":{"created_by":18,"id":"52927","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52927"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052927","sets":["2812:2813:2817"]},"author_link":["458","94313"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腸内細菌叢の有無は、薬物の体内動態に影響を与えることが知られているが、日常生活に伴う腸内細菌叢の変動が薬の効果・副作用に与える影響は報告されていない。\nそこで、食物繊維や整腸剤によりいわゆる善玉菌を増加させたモデルを作成し検討した。その結果、水溶性食物繊維投与により、善玉の腸内細菌が増殖し、肝臓において一部の代謝酵素の遺伝子発現が減少したものの、その影響は小さいものと示唆された。また整腸剤により同様に善玉の腸内細菌叢の増加が認められたが、薬物動態に与える影響は認められなかった。\n以上より日常生活での食事や整腸剤投与に伴う腸内細菌叢の変動は、薬物の体内動態に大幅な影響を与えないことが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Absence of intestinal flora Affect pharmacokinetics of drug, however there was no report whether regulation of intestinal flora by daily life affect drug safe and effective.\nThis study investigated the effects of increment of good bacteria in intestine using the animal model treated dietary fiber and medicine for intestinal disorders. The results showed that water soluble dietary fiber and medicine for intestinal disorders, which increase good bacteria, did not significantly affect pharmacokinetics factors. This study suggested that regulation of intestinal flora in dairy life would not affect pharmacokinetics of drugs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K18918, 研究期間(年度):2015-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「薬物動態変動要因としての栄養組成および腸内細菌叢環境の関与」研究成果報告書　課題番号15K18918\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18918/15K18918seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059213","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=90409384"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=90409384","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18918/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K18918/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18918/15K18918seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K18918/15K18918seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-09-10"}],"displaytype":"detail","filename":"PH-PR-SHIMADA-T-kaken 2017-4p.pdf","filesize":[{"value":"436.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-SHIMADA-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52927/files/PH-PR-SHIMADA-T-kaken 2017-4p.pdf"},"version_id":"c3dfdb20-9baa-46ae-a11e-fbd0272b3150"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"薬物動態変動要因としての栄養組成および腸内細菌叢環境の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬物動態変動要因としての栄養組成および腸内細菌叢環境の関与"},{"subitem_title":"Involvement of nutrient composition and intestinal flora on regulation factors of pharmacokinetics","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-10"},"publish_date":"2020-09-10","publish_status":"0","recid":"52927","relation_version_is_last":true,"title":["薬物動態変動要因としての栄養組成および腸内細菌叢環境の関与"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:20:06.142810+00:00"}