{"created":"2023-07-27T06:56:11.786654+00:00","id":52946,"links":{},"metadata":{"_buckets":{"deposit":"ae61b3fb-76ee-453a-a1a2-2d0c5ca0387c"},"_deposit":{"created_by":18,"id":"52946","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"52946"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00052946","sets":["2812:2813:2816"]},"author_link":["24301","2699"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2016-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"文書により同意を得た患者の手術検体から得た卵巣チョコレート嚢胞壁から間質細胞を分離し、レンチウイルスベクターシステムにて CDK4/TERTまたは、TERTのみを遺伝子導入して安定的に継代可能な不死化細胞株を樹立した。この細胞株にMPAを投与し、細胞増殖を確認したところ、内膜症組織に特有の有為な細胞増殖抑制効果を確認した。 以上より、子宮内膜症病巣由来の不死化子宮内膜間質細胞株を樹立し、以前より作成している不死化上皮細胞とともに子宮内膜症の病 態を解明する培養実験系を確立した。","subitem_description_type":"Abstract"},{"subitem_description":"Purified stromal cells isolated from ovarian endometriomas were successfully immortalised by combinatorial transfection of human cdk4 and human telomerase reverse transcriptase (hTERT) genes or hTERT genes. These cells expressed progesterone receptor B and showed significant growth inhibition by progestin.\nWe generated immortalised epithelial and stromal cells from ovarian endometrioma that retained sex steroid responsiveness. These cells are invaluable tools not only for the consistent in vitro work but also for the study of molecular pathogenesis of endometriosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K20180, 研究期間(年度):2016-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「子宮内膜症由来不死化細胞への性ホルモン受容体の遺伝子導入による病態解析」課題番号16K20180\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20180/16K20180seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00059232","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80565416"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80565416","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K20180/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K20180/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20180/16K20180seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-16K20180/16K20180seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-12"}],"displaytype":"detail","filename":"ME-PR-BONO-Y-kaken 2018-6p.pdf","filesize":[{"value":"377.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-BONO-Y-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/52946/files/ME-PR-BONO-Y-kaken 2018-6p.pdf"},"version_id":"e84934bf-23c4-4b20-b713-5b53cc1fd38e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"子宮内膜症由来不死化細胞への性ホルモン受容体の遺伝子導入による病態解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮内膜症由来不死化細胞への性ホルモン受容体の遺伝子導入による病態解析"},{"subitem_title":"Pathological analysis of immortalized endometriotic cells by introducing sex hormone receptor genes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-12"},"publish_date":"2020-10-12","publish_status":"0","recid":"52946","relation_version_is_last":true,"title":["子宮内膜症由来不死化細胞への性ホルモン受容体の遺伝子導入による病態解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:55:55.013532+00:00"}